it is now universally accepted that dna is the main target for damages caused by physical and chemical genotoxicants. although there are different methods to measure directly the induced dna damages but due to fast repair processes in cellular environment, most of the damages would be repaired even before sampling, therefore processed dna damages, i.e. damages left unrepaired after acting repai...

myocardial infarction (mi) and its major determinant, coronary artery disease (cad), are complex diseases arising from the interaction between several genetic and environmental factors. until recently, the genetic basis of these diseases was poorly understood. genome-wide genetic association studies have afforded a comprehensive insight into the association between genetic variants and diseases...

the archaeological evidence suggests that iran has been one of the first origins of sheep domestication in the world. this study aims to investigate the genetic diversity of indigenous iranian sheep breeds using mitochondrial dna (mtdna) and to explore the evolutionary history of sheep domestication in iran. single nucleotide polymorphism (snp) markers in the control region of mtdna were used t...

Helicobacter hepaticus causes chronic hepatitis and liver cancer in mice. It is the prototype enterohepatic Helicobacter species and a close relative of Helicobacter pylori, also a recognized carcinogen. Here we report the complete genome sequence of H. hepaticus ATCC51449. H. hepaticus has a circular chromosome of 1,799,146 base pairs, predicted to encode 1,875 proteins. A total of 938, 953, a...

A recommendation of: Daniel J. Richter, Cédric Berney, Jürgen F. H. Strassert, Yu-Ping Poh, Emily K. Herman, Sergio A. Muñoz-Gómez, Jeremy G. Wideman, Fabien Burki, Colomban de Vargas EukProt: database of genome-scale predicted proteins across the diversity eukaryotes https://doi.org/10.1101/2020.06.30.180687

Heat-stable nucleoid-structuring protein (H-NS) is one of the main nucleoid proteins expressed in exponentially growing Escherichia coli cells. In addition to a role in nucleoid organization, H-NS functions as a pleiotropic regulator of gene expression. The genome-wide distribution of H-NS, compared with the distribution of RNA polymerase and transcriptionally active genes, was investigated usi...

BACKGROUND Members of the genus Hafnia have been isolated from the feces of mammals, birds, reptiles, and fish, as well as from soil, water, sewage, and foods. Hafnia alvei is an opportunistic pathogen that has been implicated in intestinal and extraintestinal infections in humans. However, its pathogenicity is still unclear. In this study, we isolated H. alvei from human feces and performed se...

background although certain hbv mutations are known to affect the expression of hepatitis e antigen, their association with hbv viral level or clinical outcomes is less clear. objectives we evaluated associations between different mutations in the basal core promoter (bcp) and pre-core (pc) regions of hbv genome and subsequent changes in hbv viral dna level over seven years in a population of u...

Eukaryotes engage in a multitude of beneficial and deleterious interactions with bacteria. Hamiltonella defensa, an endosymbiont of aphids and other sap-feeding insects, protects its aphid host from attack by parasitoid wasps. Thus H. defensa is only conditionally beneficial to hosts, unlike ancient nutritional symbionts, such as Buchnera, that are obligate. Similar to pathogenic bacteria, H. d...

Haemophilus parasuis serotype 4 is a Gram-negative pathogen that is the most prevalent H. parasuis serovar in the world, but its genome sequence information has not yet been reported. Thus, we determined the genome of H. parasuis strain gx033, a serovar 4 strain isolated from a lung specimen of a diseased piglet in southwestern China. Here, we present the first draft genome sequence of this spe...