UNLABELLED Multiple system atrophy (MSA) is a fatal, rapidly progressive neurodegenerative disease with (oligodendro-)glial cytoplasmic α-synuclein (α-syn) inclusions (GCIs). Peripheral neuropathies have been reported in up to 40% of MSA patients, the cause remaining unclear. In a transgenic MSA mouse model featuring GCI-like inclusion pathology based on PLP-promoter driven overexpression of hu...

Multiple system atrophy (MSA) is a fatal neurodegenerative disorder characterized by the pathological accumulation of alpha-synuclein (α-syn) in oligodendrocytes. Therapeutic efforts to stop or delay the progression of MSA have yielded suboptimal results in clinical trials, and there are no efficient treatments currently available for MSA patients. We hypothesize that combining therapies target...

The goal of voice conversion is to transform a sentence said by one speaker, to sound as if another speaker had said it. The classical conversion based on a Gaussian Mixture Model and several other schemes suggested since, produce muffled sounding outputs, due to excessive smoothing of the spectral envelopes. To reduce the muffling effect, enhancement of the Global Variance (GV) of the spectral...

Dialectal Arabic (DA) poses serious challenges for Natural Language Processing (NLP). The number and sophistication of tools and datasets in DA are very limited in comparison to Modern Standard Arabic (MSA) and other languages. MSA tools do not effectively model DA which makes the direct use of MSA NLP tools for handling dialects impractical. This is particularly a challenge for the creation of...

Multiple system atrophy (MSA) is a fatal, rapidly progressive neurodegenerative disease with limited symptomatic treatment options. Discrimination of MSA from other degenerative disorders crucially depends on the presence of early and severe cardiovascular autonomic failure (CAF). We have previously shown that neuropathologic lesions in the central autonomic nuclei similar to the human disease ...

Modern Standard Arabic (MSA) is the formal language in most Arabic countries. Arabic Dialects (AD) or daily language differs from MSA especially in social media communication. However, most Arabic social media texts have mixed forms and many variations especially between MSA and AD. This paper aims to bridge the gap between MSA and AD by providing a framework for AD classification using probabi...

The valve mass flux Gv is the calculated value for an ideal (isentropic) nozzle Gn from an appropriate model, multiplied by a discharge coefficient Kd, which accounts for any discrepancies between the (ideal) nozzle model and flow in a real nozzle, as well as any differences between the flow in the nozzle and the actual valve: Gv = Kd Gn (2) As shown in Figure 1, there are obvious similarities ...

Multithreading is effective to solve latency and synchronization problems which are fundamental issues in parallel processing. One of multithreaded computers, DAVRID has the computational model which is based on dataflow model together with advantages of von Neumann model. In this paper, we introduce some problems of DAVRID through performance evaluation and propose new architecture, MSA(Hybrid...

BACKGROUND To investigate the relationship between presenting clinical manifestations and imaging features of multisystem neuronal dysfunction in MSA patients, using (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET). METHODS We studied 50 consecutive MSA patients with characteristic brain MRI findings of MSA, including 34 patients with early MSA-parkinsonian (MSA-P) and 16...

Evolutionary studies usually use a two-step process to investigate sequence data. Step one estimates a multiple sequence alignment (MSA) and step two applies phylogenetic methods to ask evolutionary questions of that MSA. Modern phylogenetic methods infer evolutionary parameters using maximum likelihood or Bayesian inference, mediated by a probabilistic substitution model that describes sequenc...