The drug 3, 4 diaminopyridine (DAP) is a potassium channel blocker, closely related to 4-aminopyridine. Like 4-AP, DAP blocks the voltage-sensitive potassium channel. However, unlike 4-AP, DAP does not cross the blood brain barrier unless the barrier is broken. DAP therefore should be well suited for treating peripheral demyelination and have less central nervous system mediated side-effects. M...

E. Blaufuss, G. Guillian , Y. Fukuda , S. Fukuda , M. Ishitsuka , Y. Itow , T. Kajita , J. Kameda , K. Kaneyuki , K. Kobayashi , Y. Kobayashi , Y. Koshio , M. Miura , S. Moriyama , M. Nakahata , S. Nakayama , Y. Obayashi , A. Okada , K. Okumura , N. Sakurai , M. Shiozawa , Y. Suzuki , H. Takeuchi , Y. Takeuchi , T. Toshito , Y. Totsuka , S. Yamada , M. Earl , A. Habig , E. Kearns , M.D. Messier...

Miller Fisher syndrome (MFS) was first recognized by Collier in 1932 as a clinical triad of ataxia, areflexia, and ophthalmoplegia. In 1956, three cases with this were published limited variant Guillian-Barré (GBS), the disease started to be called his name. Since beginning SARS-CoV-2 pandemic, there have been many reports peripheral central nervous system involvement. Until December 2022, tota...

Vaccinations against infectious diseases are one of the major achievements in medicine in the last century and the most effective method for preventing infections. Concern about safety of vaccinations has been heightened by several reports of possible vaccine-induced autoimmune phenomena following various vaccinations. So far no study was able to show a casual connection between any vaccine and...

The emergence of pandemic H1N1 influenza in 2009 has prompted public health responses, including production and licensure of new influenza A (H1N1) 2009 monovalent vaccines. Safety monitoring is a critical component of vaccination programs. As proof-of-concept, the authors mimicked near real-time prospective surveillance for prespecified neurologic and allergic adverse events among enrollees in...

Membrane plasma exchange (PE) is a mode of extracorporeal blood purification. Since 1985 membrane PE has been in regular use at the Department of Nephrology, Medical Faculty of Skopje, R.Macedonia. In this paper we report on five years (2000-2004) of single centre plasma exchange activity. We performed 540 PE treatments (108 PE/per year) on 99 patients. The M/F ratio was 40/48. The patients und...

BACKGROUND Acute flaccid paralysis (AFP) is clinical presentation marked by acute onset of weakness and reduced tone. Aetiologies of AFP are diverse including infectious agents, trauma or autoimmune reaction. Currently only three countries in the world that are Nigeria, Pakistan and Afghanistan have endemic poliomyelitis. Pakistan's polio crisis represents one of the last hurdles in a 23-year c...

Introduction Gastrointestinal infections caused by Campylobacter spp. can manifest as self-limited gastroenteritis or more severe diarrhoea. They can also cause secondary complications, such as reactive arthritis and Guillian-Barré syndrome. Recent publications have indicated that Campylobacter is a leading cause of food-borne diseases in many countries in Europe, clearly surpassing former fron...

BACKGROUND & OBJECTIVES Tumour necrosis factor-alpha (TNF-alpha) is regarded as one of the immune factors that can induce demyelination of peripheral nerves in patients with Guillian-Barre syndrome (GBS). This present study was undertaken to find out the role of TNF-alpha and soluble TNF receptors in the pathogenesis of GBS; and to study the effect of intravenous immunoglobulin (ivIg) therapy o...