Constitutive activation of Notch signaling is required for the proliferation of a subgroup of human T-cell acute lymphoblastic leukemias (T-ALL). Previous in vitro studies have demonstrated the therapeutic potential of Notch signaling inhibitors for treating T-ALL. To further examine this possibility, we applied a gamma-secretase inhibitor (GSI) to T-ALL xenograft models. Treatment of establish...

Purpose: Accumulating evidence supports the existence of breast cancer stem cells (BCSC), which are characterized by their capacity to self-renew anddivide indefinitely and resistance to conventional therapies. The Notch pathway is important for stem cell renewal and is a potential target for BCSC-directed therapy. Experimental Design: Using human breast tumorgraft studies, we evaluated the imp...

OBJECTIVE To assess the feasibility of visualizing hand and foot tendon anatomy and disorders by Gemstone Spectral Imaging (GSI) high-definition CT (HDCT). MATERIALS AND METHODS Thirty-five patients who suffered from hand or foot pain were scanned with GSI mode HDCT and MRI. Spectrum analysis was used to select the monochromatic images that provide the optimal contrast-to-noise ratio (CNR) fo...

More and more often, on an increasingly large scale, the geological resistance index (GSI) system is used for design practice of mining process. The GSI, a unique classifying mass rocks, linked to parameters rock strength distortion, based generalized criteria Hoek-Brown MohrCoulomb. GSI can be estimated using standard in situ tables by direct surface observations underground or mining. value p...

RÉSUMÉ. Les ingénieurs ont pour objectif de construire des systèmes d’information (SI) qui doivent satisfaire les exigences des organisations actuelles positionnées dans un environnement en perpétuelle évolution. Dans ce contexte l’ingénierie des SI est un domaine clé pour limiter le risque de non-alignement du SI aux processus métier. La gouvernance des SI (GSI) a la responsabilité des process...

The concept of Genealogical Sorting Indexes (GSIs) was first introduced by Cummings et al. [1]. Given a set of observations belonging to different groups (represented in the form of a hierarchial tree), the Genealogical Sorting Index (GSI) value obtained for a particular group provides a quantitative measure of how closely the observations belonging to this group have clustered in the given tre...

13 The Genealogical Sorting Index (gsi) has been widely used in species-delimitation studies, where 14 it is usually interpreted as a measure of the degree to which each of several predefined groups of 15 specimens display a pattern of divergent evolution in a phylogenetic tree. Here we show that the gsi 16 value obtained for a given group is highly dependent on the structure of the tree outsid...

Grid Portals, based on standard Web technologies, are increasingly used to provide user interfaces for Computational and Data Grids. However, such Grid Portals do not integrate cleanly with existing Grid security systems such as the Grid Security Infrastructure (GSI), due to lack of delegation capabilities in Web security mechanisms. We solve this problem using an online credentials repository ...

Self-incompatibility (SI) is found in approximately 40% of flowering plant species and at least 100 families. Although orchids belong to the largest angiosperm family, only 10% of orchid species present SI and have gametophytic SI (GSI). Furthermore, a majority (72%) of Dendrobium species, which constitute one of the largest Orchidaceae genera, show SI and have GSI. However, nothing is known ab...

Self-incompatibility (SI) is widespread in the angiosperms, but identifying the biochemical components of SI mechanisms has proven to be difficult in most lineages. Coffea (coffee; Rubiaceae) is a genus of old-world tropical understory trees in which the vast majority of diploid species utilize a mechanism of gametophytic self-incompatibility (GSI). The S-RNase GSI system was one of the first S...