It has been suggested (P. W. Brian, Trans. Brit. Mycol. Soc. 43:1, 1960) that the antibiotic griseofulvin affects only those fungi possessing chitin in their cell wall, but there is a growing body of evidence which makes it unlikely that the presence of chitin is the sole prerequisite for the action of the antibiotic. For instance, K. J. Bent and R. H. Moore (Biochemical Studies of Anti-microbi...

Palm-based lipid nanoparticle formulation loaded with griseofulvin was prepared by solvent-free hot homogenization method. The griseofulvin loaded lipid nanoparticles were prepared via stages of optimisation, by altering the high pressure homogenisation (HPH) parameters, screening on palm-based lipids and Tween series surfactants and selection of lipid to surfactant ratios. A HPLC method has be...

background : dermatophytosis is the common cutaneous infections in humans and animals, which is caused by the keratinophylic fungus called dermatophytes. in recent years , drug-resistance in pathogenic fungi, including dermatophytes to the current antifungal have been increased . the aim of this study was to evaluate the antifungal efficacy of agnps against microsporum canis, trichophyton menta...

results presence of soy pc improved mechanical properties, lowered swelling ratio and increased stability of the films. solubilizing activity of phospholipid resulted in higher flux of drug release from formulation containing higher amount of soy pc. antifungal efficacy of formulations was confirmed against two species of dermatophytes in vitro. conclusions this topical composite film had the p...

Background: Tinea capitis is a relatively common fungal infection in children. Although several oral anti-fungal agents have been used in the treatment of tinea capitis, griseofulvin has been considered as the treatment of choice for a long time. Objective: To compare the therapeutic effects of fluconazole with griseofulvin on tinea capitis. Patients and Methods: Through a randomized, single-bl...

Wehave studied the microbial transformation of griseofulvin (I) by Cephalosporium curtipes and the formation of two more polar metabolites was observed in a proportion of 10:1. The compounds have been identified as (+)-5'-hydroxygriseofulvin (axial) (II) and G'-hydroxymethylgriseofulvin (III) (Fig. 1). The microbial transformation of griseofulvin was performed by a 48-hour-old culture of Cephal...

Practice guidelines for the treatment of tinea capitis (TC) from the European Society for Pediatric Dermatology are presented. Tinea capitis always requires systemic treatment because topical antifungal agents do not penetrate the hair follicle. Topical treatment is only used as adjuvant therapy to systemic antifungals. The newer oral antifungal agents including terbinafine, itraconazole, and f...

Topical therapy is highly desirable in treating nail disorders due to its localized effects, which results minimal adverse systemic events and possibly improved adherence. However, the effectiveness of topical therapies limited by drug permeability through plate. Infections foot hand nails fungi are a very common condition millions people. They account for about half all estimated occur over 10...

A large portion of natural products research revolves around the discovery of new, bioactive chemical entities; however, studies to probe the biological purpose of such secondary metabolites for the host organism are often limited. Mass spectrometry mapping of secondary metabolite biosynthesis in situ can be used to probe a series of ecological questions about fungi that may be lost through tra...