PURPOSE OF REVIEW Hyperkinetic movement disorders can manifest alone or as part of complex phenotypes. In the era of next-generation sequencing (NGS), the list of monogenic complex movement disorders is rapidly growing. This review will explore the main features of these newly identified conditions. RECENT FINDINGS Mutations in ADCY5 and PDE10A have been identified as important causes of chil...

Introduction: NMDA receptors are involved in the pathogenesis of seizures, as it subunit is coded for by GRIN1 gene. Different mutations known patients with different forms epilepsy and encephalopathy. However, no data available on participation gene its polymorphisms development post-traumatic (PTE). Aim: To determine influence single-nucleotide rs1126442 polymorphism risk PTE formation. Mater...

Medial ganglionic eminence (MGE)-derived parvalbumin (PV)+, somatostatin (SST)+and Neurogliaform (NGFC)-type cortical and hippocampal interneurons, have distinct molecular, anatomical, physiological properties. However, the molecular mechanisms regulating their maturation remain poorly understood. Here, via single-cell transcriptomics, we show that obligate NMDA-type glutamate receptor (NMDAR) ...

Results: The anxiety indices of the traumatized rats were markedly higher than those of the controls (p<0.05). GluN1 and calmodulin levels were decreased in the dorsal hippocampus and amygdaloid complex of the traumatized rats. NOS expression increased significantly in both the amygdaloid complex and dorsal hippocampus where the increase was statistically more prominent in the amygdaloid comple...