Based on the structures of identified active ingredients, the phenolic compounds extracted from grape seeds and pine bark would not be expected to be genotoxic. Indeed, the inventor of pycnogenol states that this product was tested in Salmonella typhimurium and was negative. Substantial health claims for grape seed and pine bark extracts, including some studies showing tumor inhibition, make th...

Vitis vinifera, known as the grapevine, is native to southern Europe and Western Asia. Grape seed and skin contain several active components including flavonoids, polyphenols, anthocyanins, proanthocyanidins, procyanidines, and the stilbene derivative resveratrol. Grape seed extract in particular has been reported to possess a broad spectrum of pharmacological and therapeutic effects such as an...

Phenolic compound profiles were investigated by HPLC-MS in two consecutive years to assess genotypic variation in berry skins of nine red Vitis vinifera cultivars. The results showed that the types and levels of phenolic compounds greatly varied with cultivar. Common wine grape cultivars such as Syrah, Cabernet Sauvignon, Cabernet Gernischt and Merlot contained more types of anthocyanins, flavo...

Chloasma (melasma), an acquired hypermelanosis, is often recalcitrant to various treatments and an amenable, as well as safe, pigment-reducing modality is needed. We investigated that the reducing effect of proanthocyanidin, a powerful antioxidant, on chloasma in a one-year open design study. Proanthocyanidin-rich grape seed extract (GSE) was orally administered to 12 Japanese woman candidates ...

A seed-specific 2S albumin gene and its promoter region of grape (Vitis vinifera L.) were isolated using an improved thermal asymmetric interlaced PCR that allowed efficient amplification of target sequence of up to 3 kbp in length directly from genomic DNA. The 2S albumin VvAlb1 (for V. vinifera 2S albumin 1) gene from different grape cultivars encompasses a coding region of 504-540 nucleotide...

Descriptive sensory analysis, instrumental color, yield, pH, water activity, and binding strength were determined on ground chicken breast and thigh with or without grape seed extract (GSE) during refrigerated storage. In chicken breast, GSE inhibited the intensity of musty and rancid odor, and rancid flavor compared to control patties, but GSE caused significantly darker (L(∗)), redder (a(∗)),...

Based on the structures of identified active ingredients, the phenolic compounds extracted from grape seeds and pine bark would not be expected to be genotoxic. Indeed, the inventor of pycnogenol states that this product was tested in Salmonella typhimurium and was negative. Substantial health claims for grape seed and pine bark extracts, including some studies showing tumor inhibition, make th...

Today in the wine industry, oenological tannins are widely used to improve wine quality and prevent oxidation in wine aging. With the development of tannin products, new oenological tannins are developed with many specific functions, such as modifying antioxidant effect, colour stabilization and aroma modifications. The aim of this work is to investigate effects of pre-fermentative addition of ...

ABSTARCT Grape (Vitis vinifera) seed extract found to be exhibits wide range of beneficial effects insights to screen the potential compounds which includes polyphenolic compounds both flavonoids and non-flavonoids that show antioxidant effects. In this present study phytochemical screening of alkaloids, flavonoids, glycosides, polyphenol and flavonoids, tannins, and sterols were presented in t...