Neonatal Sepsis is one of the most common reasons for admission to neonatal units in developing countries. It is also a major cause of mortality in both developed and developing countries. Identification of the common bacteria and risk factors causing such infections and their susceptibility patterns will provide necessary information for timely intervention. This study was carried out to deter...

International guidelines concerning the management of patients with sepsis, septic shock and multiple organ failure make no reference to the nature of the infecting organism. Indeed, most clinical signs of sepsis are nonspecific. In contrast, in vitro data suggest that there are mechanistic differences between bacterial, viral and fungal sepsis, and imply that pathogenetic differences may exist...

A prospective observational study was conducted in a neonatal unit of referral teaching hospital North India with an aim to the bacteriological profile and sensitivity pattern referred neonates. During this period one year, incidence culture positive sepsis 34 % among which gram-negative bacilli predominated both early onset late sepsis. In sepsis, predominant organism Klebsiella pneumoniae fol...

Abstract Background The role of intestinal microbiota in the pathogenesis late-onset sepsis (LOS) preterm infants is largely unexplored but could provide opportunities for microbiota-targeted preventive and therapeutic strategies. We hypothesized that composition changes before onset sepsis, with causative bacteria are isolated later blood culture. Methods This multicenter case-control study in...

neonatal bacterial sepsis is one of the major cause of morbidity and mortality in neonates. this retrospective study was performed to determine the incidence of bacterial sepsis with focus on gram negative organisms in neonates admitted at beheshti hospital in kashan, during a 3-yr period, from september 2002 to september 2005. blood culture was performed on all neonates with risk factors or si...

OBJECTIVE With improving rates of initial survival in severe sepsis, second-hit infections that occur following resolution of the primary insult carry an increasing burden of morbidity. However, despite the clinical relevance of these infections, no data are available on differential outcomes in patients with first and second-hit infections depending on the nature of the causative organism. Thi...

bacterial sepsis is one of the most common causes of mortality and morbidity in neonates. it has been recognized a gradual change in spectrum of organisms responsible for neonatal sepsis. in this study we have evaluated changing trend of incidence and antibiotic susceptibility in neonatal late - onset sepsis (los) in 2-periods. this study is based on results of blood culture in neonatal late-on...

Blood-culture results for a 15-year period from a large southern hospital were tabulated and analyzed for alterations in the bacterial species associated with bacteremia. From 15,543 cultures, 2,410 positive cultures (15.6%) were obtained. These results were grouped into 5-year periods, and an alteration in the incidence of the agents was demonstrated. In the past 5 years, gram-negative bacilli...

Linezolid has been widely used in the treatment of Gram-positive infections for more than a decade. It is unique amongst antibiotics active against most multiply-resistant Gram-positive bacteria in that there is an oral preparation with 100% bioavailability and an extensive volume of distribution. This review examines pharmacokinetic data relating to linezolid use in different patient groups (o...

Purpura fulminans is a hemorrhagic condition associated predominantly with meningococcal and other gram negative septicemias. It occurs mainly in infants and younger children. Features include tissue necrosis, small vessel thrombosis, disseminated intravascular coagulation, multi-organ failure and death. Other causes include clotting factor deficiencies and idiopathic varieties. The condition i...