The development and progression of lung adenocarcinoma, one of the most common cancers, is driven by the interplay of genetic and epigenetic changes and the role of chromatin structure in malignant transformation remains poorly understood. We used systematic nucleosome distribution and chromatin accessibility microarray mapping platforms to analyze the genome-wide chromatin structure from norma...

Adenocarcinoma no otherwise specified (NOS) and polymorphous low-grade adenocarcinoma (PLGA), are malignant tumors of the salivary glands. Both types have potential for recurrence distant metastases. Rare cases metastases lead to absence standardized systemic therapy gland cancer. This case report aims expand literature regarding parotid adenocarcinoma. We a 54-year-old woman who complained rec...

Barrett's oesophagus is the premalignant precursor of oesophageal adenocarcinoma. Non-dysplastic metaplasia can progress to low-grade dysplasia, high-grade dysplasia, and finally to invasive cancer. Although the frequency of adenocarcinoma in patients with Barrett's oesophagus is low, surveillance is justified because the outcome of adenocarcinoma is poor. Oesophagectomy remains the standard tr...

nasal sinuses representing about 70% of malignant tumors. Only between 10% and 20% correspond to adenocarcinomas mostly originated in the minor submucous glands. Less frequent tumors originate in the cavity lining epithelium, such as intestinal-type adenocarcinoma (ITA) and low-grade adenocarcinoma (LGA). The ITA, described by Jarvi in 1945 1 , is also known as mucinous adenocarcinoma, colon ad...

A 70 year old male presented with right lower quadrant pain and anorexia for about 72 hours prior to hospital admission. He underwent laparotomy with impression of acute appendicitis. The operative finding was an inflamed tumoral appendix without appendicular base involvement, and appendectomy was done. The patient had an uneventful post-op course. Due to the pathology report of prostatic ...

BACKGROUND Accurate population-based data are needed on the incidence of esophageal adenocarcinoma and high-grade dysplasia among patients with Barrett's esophagus. METHODS We conducted a nationwide, population-based, cohort study involving all patients with Barrett's esophagus in Denmark during the period from 1992 through 2009, using data from the Danish Pathology Registry and the Danish Ca...

Dedifferentiation is defined as high-grade malignant tumor development out of a low-grade malignant tumor. We present an adenocarcinoma tumor of the parotid gland that was dedifferentiated from a low-grade epithelial-myoepithelial carcinoma and was followed up for 3 years. Our patient, a 46-year-old female, presented with a left parotid mass of 20-year duration. Histopathologic results showed t...

Low-grade nasopharyngeal papillary adenocarcinoma is an extremely rare tumor, with only a limited number of cases reported in the literature. Some published studies have paid more attention to the clinicopathological features of nasopharyngeal adenocarcinoma, while little effort has been made to study the optimal therapeutic strategies. We report about a woman diagnosed with low-grade nasophary...