BACKGROUND Adriamycin (ADR) is a potent chemotherapeutic agent widely used in the treatment of childhood acute lymphoblastic leukemia (ALL); its clinical use is limited owing to its marked cardiotoxicity. The present study investigated the possible protective role of carvedilol on ADR-induced left ventricular dysfunction in children with ALL. METHODS AND RESULTS Fifty children with newly diag...

An economically eficient and eflective transportation system is one of the essential components for the economic and sociai weil-being of agribu~”ness~rms that provi& agricultural andfoodproducls to consumers and end-users in the state. One possible methdfor improving that system is the use of tnteliigent Transportation Systems (ITSS). ITSS are systems that encompass several technologies, inclu...

BACKGROUND Identification of active or sedentary modes of transport is of relevance for studies assessing physical activity or addressing exposure assessment. We assessed in a proof-of-principle study if speed as logged by GPSs could be used to identify modes of transport (walking, bicycling, and motorized transport: car, bus or train). METHODS 12 persons commuting to work walking, bicycling ...

Considerable efforts have recently been made to understand and identify various spatio-temporal transitions from an unstable state to a coherently oscillating or chaotic state in numerous hydrodynamic flows. Oscillatory convection in binary mixtures as well as a variety of open-flow systems show a transition to spatially developing traveling waves (TW). For these systems a generalized Ginzburg-...

For the seismic vulnerability and risk assessment of school infrastructure in a region, it becomes necessary first to identify classify these constructions into distinct number structural typologies characterised by their features. This enables us rank expected different at initial screening stage as well characterise representative index buildings for detailed quantification. Currently, system...

Matrix-analytic method for the analysis of finite M2|M2|1|R queueing system with bi-level hysteric policy that models signalling hop-by-hop load control mechanism for SIP server is presented. Algorithm for efficient computation of of joint stationary probability distribution and expressions for some performance characteristics are given. Illustrative numerical example is provided to demonstrate...