A new array-based technology for the simultaneous capture, chemical labelling and mass spectrometry analysis of peptides is presented. Isotopically labelled self-assembled monolayer (SAM) gold arrays are constructed and used simultaneously to capture and label a range of peptides. The array-immobilised, labelled peptides were released by MALDI ablation, analysed by MALDI mass spectrometry and r...

Plasma and other body fluids contain cell-derived extracellular vesicles (EVs), which participate in physiopathological processes and have potential biomedical applications. In order to isolate, concentrate and purify EVs, high-speed centrifugation is often used. We show here, using electron microscopy, receptor-specific gold labelling and flow cytometry, that high-speed centrifugation induces ...

A two-photon fluorescence labelling probe (LP) was synthesised, and LP-Ag obtained by LP the N-protein antigen (Ag) of COVID-19. made into an immunochromatographic strip. When a blood sample added to hole test card, it would move forward along nitrocellulose (NC) film. If contained IgM, IgM bound formed M line with coated mouse anti-human antibody, giving positive response presence The sensitiv...

We describe a robust approach for linking already existing lexical/semantic hierarchies. We use a constraint satisfaction algorithm (relaxation labelling) to select –among a set of candidates– the node in a target taxonomy that bests matches each node in a source taxonomy. In this paper we present the complete mapping of the nominal, verbal, adjectival and adverbial parts of WordNet 1.5 onto Wo...