OBJECTIVE To determine how iodine deficiency and endemic goitre disappeared in Britain. DESIGN Review of surveys of endemic goitre and iodine nutrition. MAIN RESULTS Endemic goitre was widespread in Britain but has declined, most notably since the 1960's. Its disappearance was probably due to changes in farming practice, especially iodine supplementation in dairy herds which has resulted in...

In the course of medical inspection of school children of Mulepur, a village in Kabirwala talisilit was noticed that a remarkably larg-e number of children suffered from simple goitre. Out of a total number of 70 boys examined, 32 were found to be suffering from goitre?a very high percentage. Further investigation showed that goitre exists not only amongst the students of the 1st and 5th classe...

The relationship between thyroid auto-immunity and the presence of lymphocytes in the thyroid gland has been analysed in patients with Graves' disease, toxic adenoma, and non-toxic nodular goitre. In all these conditions circulating antibody to thyroglobulin was significantly associated with lymphocytic infiltration. No similar correlation was established in the case of the complement-fixing an...

Goitres usually enlarge and descend caudad into the substernal space and are not palpable. We report on a patient whose goitre spread downward but anterior to the sternum. The thyroid mass was subsequently removed and was proven to be a papillary thyroid carcinoma. The mechanism by which a presternal goitre develops is probably due to invasion and erosion of the strap muscles and the cervical l...

Of 330 patients given lithium for recurrent manic-depressive disorder 12 developed goitre after treatment periods of five months to two years. All the patients remained clinically euthyroid. Pressure symptoms necessitated subtotal thyroidectomy in two patients. In 9 out of 10 patients with goitre, and in two out of seven without goitre study with radioactive iodine showed abnormal findings in i...