Pumpkin seed oil (PSO) possesses a protective potential against liver injury due to the presence of biologically active ingredients. Adult male albino rats were administrated PSO (per os, 2 mL/kg b.w./day) and 12% ethanol solution in water, ad libitum, with an average intake 8.14 g ethanol/kg bw/day for 6 weeks. Congestion, hepatic central vein dilation, portal branch Kupffer cell hyperplasia, ...

Platyhelminth parasites are a major health problem in developing countries. In contrast to their mammalian hosts, platyhelminth thiol-disulfide redox homeostasis relies on linked thioredoxin-glutathione systems, which are fully dependent on thioredoxin-glutathione reductase (TGR), a promising drug target. TGR is a homodimeric enzyme comprising a glutaredoxin domain and thioredoxin reductase (TR...

The present study evaluates the genotoxic potential of different soil samples collected from rice fields employing Allium cepa root chromosomal aberration assay using in situ and root dip modes of treatment. The study also involves assessment of oxidative stress by analyzing responses of certain antioxidative enzymes viz. catalase (CAT), ascorbate peroxidase (APX), glutathione reductase (GR), g...

supplementation has beneficial effects in immune system and can antioxidant enzymes activity increases during the exercise and protects the tissue against the oxidative stress. l-carnitine is a famous supplement and helps to protect against the oxidative stress during and after intense or prolonged exercise. the aim of this study was to investigate the effect of l-carnitine supplementation on t...

Reduced forms of ascorbate (AsA) and glutathione (GSH) are among the most important non-enzymatic foliar antioxidants in maize (Zea mays L.). The survey was aimed to evaluate impact of bird cherry-oat aphid (Rhopalosiphum padi L.) or grain aphid (Sitobion avenae F.) herbivory on expression of genes related to ascorbate-glutathione (AsA-GSH) cycle in seedlings of six maize varieties (Ambrozja, N...

AIMS We have previously shown that exercise leads to sustainable cardioprotection through a mechanism involving improved glutathione replenishment. This study was conducted to determine if redox-dependent modifications in glutathione reductase (GR) were involved in exercise cardioprotection. Furthermore, we sought to determine if reactive oxygen species generated by NADPH oxidase and/or mitocho...

Glucose-6-phosphate dehydrogenase (G6PDH)-deficient cells of Saccharomyces cerevisiae showed increased susceptibility and were unable to induce adaptation to oxidative stress. Historically, mainly in human erythrocytes, it has been suggested and accepted that decreased cellular GSH, due to loss of the NADPH-dependent activity of glutathione reductase (GR), is responsible for the increased sensi...

Studies on oxidative stress physiology molluscs to monitor the aquatic environment, influenced by pollutants and stressors are very limited in general Indian apple snails, P. globosa particular. The main focus of present study was establish baseline data a redox regulatory system sampled across subcontinent. Snails were from different zones India three seasons (rainy, summer winter) (levels ant...

Exposure of the lung epithelium to reactive oxygen species without adequate antioxidant defenses leads to airway inflammation, and may contribute to lung injury. Glutathione peroxidase catalyzes the reduction of peroxides by oxidation of glutathione (GSH) to glutathione disulfide (GSSG), which can in turn be reduced by glutathione reductase (GR). Increased levels of GSSG have been shown to corr...

Cotton (Gossypium hirsutum L.) seedlings are considered to be sensitive to temperature stress. The exposure of plants to high and low temperatures can result in the production of reactive oxygen species that contribute to diminished plant performance. Plants have mechanisms that metabolize oxidants into less harmful chemicals, and enhancement of antioxidant metabolism has been shown to be benef...