Background Liver enzyme abnormalities are common in patients with type 2 diabetes. Currently, the inverse relationship between elevated liver enzymes and antidiabetics intake may be explained by rigorous treatment and good control. However, few studies have directly explored the influence of antidiabetics on abnormal liver function, especially the comparison between two insulin sensitizers-thia...

BACKGROUND Elevated aminotransferases serve as surrogate markers of non-alcoholic fatty liver disease, a feature commonly associated with the metabolic syndrome. Studies on the prevalence of fatty liver disease in obese children comprise small patient samples or focus on those patients with liver enzyme elevation. OBJECTIVES We have prospectively analyzed liver enzymes in all overweight and o...

OBJECTIVE This study was undertaken to determine the prevalence, epidemiology, and mother-child repercussions of increased alanine-aminotransferase levels from week 16 of pregnancy. STUDY DESIGN A longitudinal observational study of 381 pregnant women. The cause of increased alanine-aminotransferase levels during pregnancy and repercussions on the neonate were studied in 283 cases. Statistica...

AIM To evaluate the main platelet volume (MPV) as a severity marker in patients with primary biliary cirrhosis (PBC). MATERIALS AND METHODS Thirty-nine patients with biopsy-proven and as yet untreated PBC followed between January 2008 and January 2015 were included in this study. Liver biopsies were categorized as early stage (stage 1 and 2 according to Scheuer's histological stage) and late ...

Alcohol is a major contributor to the global burden of disease, disability, and death in high, middle, and low-income countries. Harmful use of alcohol is one of the main factors contributing to premature deaths and avoidable disease burden worldwide and has a major impact on public health. The aim of this present cross-sectional study was to investigate the effect of alcohol consumption on coa...

This study was planned to evaluate the liver function in patients with type 2 diabetes mellitus by measuring bilirubin (total and direct), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT), total protein, albumin and glycosylated hemoglobin (HBA1c) .The study was carried out in Santosh Medical College & Hospital, Ghaziabad. 100 patients with t...

Objective. To characterize early risk factors of moderate/severe hepatotoxicity in a pediatric population with acetaminophen overdose, due to suicide attempt, admitted to a general secondary-level pediatric department. Methods. A retrospective case study of 107 patients, 11 to 15 years old. Results. There was a highly significant relationship between the number of episodes of prehospital vomiti...

In an analysis of the clinical and laboratory variables that can influence the response to interferon alfa-2b treatment, 48 patients with chronic hepatitis C virus infection received interferon 5 million units (MU) subcutaneously three times weekly for eight weeks followed by 3 MU three times weekly for seven months. Response related factors on univariate analysis were found to be age > 40 year...

Increased liver enzyme activities are sensitive indicators of primary hepatic disease, but they are also associated with extrahepatic diseases. The patient's signalment, clinical status, and pattern of liver enzyme activity can help in interpreting findings. The three basic liver enzyme patterns are (1) cholestatic, (2) hepatocellular leakage, and (3) mixed. Predominant increases in the activit...

VOLUME 53, NO. 7, 2001 Individuals with choledocholithiasis (common bile duct stones or CDL) can present with biliary colic, nonspecific abdominal pain, obstructive jaundice, cholangitis, or acute biliary pancreatitis. Individuals may also harbor asymptomatic stones that are diagnosed serendipitously. The diagnostic studies available are imperfect, and therapies range from expectant management ...