The physiological cholesterol-lowering benefits of β-glucan have been well documented, however, whether modulation of gut microbiota by β-glucan is associated with these physiological effects remains unknown. The objectives of this study were therefore to determine the impact of β-glucan on the composition of gut microbiota in mildly hypercholesterolemic individuals and to identify if the alter...

Water-insoluble glucan was isolated from the baker's yeast Saccharomyces cerevisiae. The yeast cells were treated with alkali and the residue then with acid. Chemical and NMR (1D and 2D) analyses showed that a linear (1→3)-β-glucan was purified that was not contaminated with other carbohydrates, proteins or phenolic compounds. The effects of the glucan on wound healing were assessed in human ve...

β-Glucans extracted from barley, which mainly contains β-(1,3-1,4)-D-glucan, are used extensively as supplements and food additives due to their wide biologic activities, including a reduction in blood lipid level. In this study, the antioxidant activity of β-glucan was examined to assess potential new benefits associated with β-glucan, because oxidative stress is considered one of the primary ...

Effects of β-glucan on innate immune responses and survival were studied in pacu experimentally infected with Aeromonas hydrophila. Fish fed diets containing 0, 0.1% and 1% β-glucan were injected with A. hydrophila. β-glucan enhanced fish survival in both treated groups (26.7% and 21.2% of the control, respectively). Leukocyte respiratory burst and alternative complement pathway activities were...

A mutation in Aspergillus nidulans led to a loss of both melanin and ca-(1,3)glucan, a major wall polysaccharide. In addition, the mutation prevented the formation of cleistothecia. Mutant walls contained increased amounts of ,B(1,3)-glucan and galactose polymers, and electron micrographs indicated that they had lost the outermost wall layer. Such walls were more readily digested by lytic enzym...

the increasing tendency for health oriented products caused considerable research has studied on increase and maintaining quality of different products. sponge cake is one of the cereal products which itsmain problems arereterogradation and lack of soluble dietary fibers which has many health benefits. in this research, therefore, the effects of adding oat β-d-glucan on the physical properties ...

As a result of the relatively few available antifungals and increasing frequency resistance to them, development novel is increasingly important. The plant natural product poacic acid (PA) inhibits ?-1,3-glucan synthesis in Saccharomyces cerevisiae has antifungal activity against wide range pathogens. However, mode action PA unclear. Here, we reveal that specifically binds ?-1,3-glucan, its aff...

β-(1,3)-Glucan, the major fungal cell wall component, ramifies through β-(1,6)-glycosidic linkages, which facilitates its binding with other cell wall components contributing to proper cell wall assembly. Using Saccharomyces cerevisiae as a model, we developed a protocol to quantify β-(1,6)-branching on β-(1,3)-glucan. Permeabilized S. cerevisiae and radiolabeled substrate UDP-(14C)glucose allo...

UNLABELLED The walls of infectious pathogens, which are essential for transmission, pathogenesis, and diagnosis, contain sugar polymers that are defining structural features, e.g., β-1,3-glucan and chitin in fungi, chitin in Entamoeba cysts, β-1,3-GalNAc in Giardia cysts, and peptidoglycans in bacteria. The goal here was to determine in which of three walled forms of Toxoplasma gondii (oocyst, ...

Fig. 1. Effect of mutastein on the formation of artificial plaque on Nichrome-steel wires by Streptococcus mutans 671 5. Experimental conditions were described in the text. 1; Control, 2; 15 ^g/ml mutastein, 3; 50 ^g/ml mutastein. It is believed to be a significant step for the induction of dental caries that cariogenic Streptococcus mutans synthesizes adhesive, insoluble glucan from sucrose an...