The retrospective study was carried out to examine performance of Pottels height- independent equation compared to Schwartzs height-dependent equation to estimate glomerular filtration rate in 115 children in Indian setting. The Pottels equation performed well compared to updated Schwartz equation (R2=0.94, mean bias 0.25, 95% LOA=20.4, -19.9). The precision was better at lower range of estimat...

It has previously been shown that inulin clearance, diodrast clearance, and diodrast Tm are significantly lower in males between the ages of 60 and 80 years than in males 20-40 years of age (1, 2). The clearance and Tm values commonly used as norms are based on averages calculated from observations made on subjects between the ages of 17 and 68 years (3-5). The present study was undertaken to e...

1. Effective renal plasma flow, glomerular filtration rate and cardiac output were measured in osmotically loaded dogs before and during comparable acute respiratory and metabolic acidosis. 2. Urine output increased in control dogs and in animals with metabolic acidosis, but declined with respiratory acidosis. Effective renal plasma flow and glomerular filtration rate declined with respiratory ...

BACKGROUND In critically ill patients with acute kidney injury, estimates of kidney function are used to modify drug dosing, adjust nutritional therapy and provide dialytic support. However, estimating glomerular filtration rate is challenging due to fluctuations in kidney function, creatinine production and fluid balance. We hypothesized that commonly used glomerular filtration rate prediction...

Shannon and Smith (1) found that in normal man, the rate of excretion of inulin was directly proportional to its concentration in plasma when the latter varied from 50 to 400 mg. per cent. Later Miller, Alving, and Rubin (2). extended these observations to plasma concentrations of inulin between 3 and 96 mg. per cent and reached similar conclusions. Both groups considered that this constituted ...

The mechanism of glomerular ultrafiltration in normal kidneys or after renal injury is reviewed. The role of increased glomerular plasma flow in mediating increases of nephron filtration rate is evidenced under experimental conditions resulting in filtration pressure disequilibrium along glomerular capillaries. The increase of nephron filtration in hypertrophied kidneys appears to be due mainly...

An experimental model of postischemic, acute renal failure has been developed in Wistar rats with surface glomeruli, thereby making possible a direct assessment of the mechanisms responsible for the fall in glomerular filtration rate that characterizes this disorder. Whole kidney and cortical single nephron filtration rates were reduced proportionately, on average by approximately 40%, after 3 ...