نتایج جستجو برای: globoid cell leukodystrophy
تعداد نتایج: 1684780 فیلتر نتایج به سال:
In [Dr1], V. Drinfeld has introduced the analogues of Shimura varieties for GLd over a global field F of positive characteristic. Following a suggestion of U. Stuhler the corresponding varieties for an inner form of GLd, i.e. the group of invertible elements A of a central simple algebra A of dimension d over F , have been introduced by Laumon, Rapoport and Stuhler in [LRS]. For d = 2 these are...
Journal of Lipid Research Volume 54, 2013 3303 Copyright © 2013 by the American Society for Biochemistry and Molecular Biology, Inc. Globoid cell leukodystrophy (GLD) is a rapidly progressing pediatric neurodegenerative disease caused by missing or dysfunctional lysosomal enzyme galactosylceramidase (GALC). Hallmarks of this disease include macrophage (globoid cell) infi ltration into the brain...
ClC-2 is a broadly distributed chloride channel with an enigmatic neurophysiological function. In this issue of Neuron, Jeworutzki et al. (2012) use a biochemical approach to identify GlialCAM, a protein with a defined link to leukodystrophy, as a ClC-2 auxiliary subunit.
The balance between survival and death in many cell types is regulated by small changes in the intracellular content of bioactive sphingolipids. Enzymes that either produce or degrade these sphingolipids control this equilibrium. The findings here described indicate that the lysosomal galactocerebrosidase (GALC) enzyme, defective in globoid cell leukodystrophy, is involved in the maintenance of...
Globoid cell leukodystrophy (GLD), or Krabbe disease, is a rare and often fatal demyelinating disease caused by mutations in the galactocerebrosidase (galc) gene that result in accumulation of galactosylsphingosine (psychosine). We recently reported that the extracellular matrix (ECM) protease, matrix metalloproteinase-3, is elevated in GLD and that it regulates psychosine-induced microglial ac...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید