for which we are very grateful. All the authors and investigators of dementia studies who provided us more specific data from their work. foreword Today, over 46 million people live with dementia worldwide, more than the population of Spain. This number is estimated to increase to 131.5 million by 2050. Dementia also has a huge economic impact. Today, the total estimated worldwide cost of demen...

INTRODUCTION Neuropsychological assessment of patients with dementia necessitates the use of varied memory tasks designed to measure different memory processes, including information memorization, retention and retrieval. A valid memory battery should be demonstrated to discriminate between demented and non-demented subjects and its scores should be related to the degree of intellectual impairm...

BACKGROUND The transition from mild cognitive impairment (MCI) to Alzheimer's disease is characterized by a decline in cognitive performance in many domains. Cognitive performance profiles in MCI are heterogeneous, however, and additional insights into markers of incipient dementia are needed. Typically, studies focus on average or mean performance, but ignore consistency of performance across ...

BACKGROUND Neuroimaging-biomarkers of Mild Cognitive Impairment (MCI) allow an early diagnosis in preclinical stages of Alzheimer's disease (AD). The goal in this paper was to review of biomarkers for Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD), with emphasis on neuroimaging biomarkers. METHODS A systematic review was conducted from existing literature that draws on markers a...

OBJECTIVES To define the cognitive characteristics of Pick disease (PcD), and to determine which features distinguish PcD from Alzheimer disease (AD), in a cross-sectional and longitudinal study. METHODS The participants were 44 patients with PcD (10 pathologically verified), 121 patients with AD (14 pathologically verified), and 60 normal control subjects. We obtained information regarding t...

OBJECTIVE To examine whether observed differences in dementia rates between black and white older people living in the community could be explained by measures of socioeconomic status (income, financial adequacy, education, and literacy) and health related factors. DESIGN Prospective cohort study. SETTING General community from two clinic sites in the United States (Pittsburgh, Pennsylvania...

Graph Shift (GS) algorithms are recently focused as a promising approach for discovering dense subgraphs in noisy data. However, there are no theoretical foundations for proving the convergence of the GS Algorithm. In this paper, we propose a generic theoretical framework consisting of three key GS components: simplex of generated sequence set, monotonic and continuous objective function and cl...

The Robust Graph mode seeking by Graph Shift [1] (RGGS) algorithm represents a recent promising approach for discovering dense subgraphs in noisy data. However, there are no theoretical foundations for proving the convergence of the RGGS algorithm, leaving the question as to whether an algorithm works for solid reasons. In this paper, we propose a generic theoretical framework consisting of thr...

Cognitive decline associated with old age and consistent with the diagnosis of primary degenerative dementia is a unique clinical syndrome with characteristic phenomena and progression. The authors describe a Global Deterioration Scale for the assessment of primary degenerative dementia and delineation of its stages. The authors have used the Global Deterioration Scale successfully for more tha...