The Gleason grading system is a standard method of assessing prostate cancer. Very little is known, however, about the person behind the system, Donald Floyd Gleason, MD, PhD. Our objective was to construct a biography of Gleason and show how his work advanced prostate cancer diagnosis. We reviewed Gleason's notes, letters, and publications with the Veteran's Administration Cooperative Urology ...

CONTEXT In 2005, the International Society of Urologic Pathology consensus conference recommended that men with biopsy Gleason score 3 + 4 or 4 + 3 prostate cancer and tertiary pattern 5 should have their cancer classified as Gleason score 8 or 9, respectively. Yet, the management of men with Gleason score 7 vs 8 or 9 prostate cancer differs. OBJECTIVE To compare the prognostic significance o...

OBJECTIVE The objective of our study was to determine the relationship between the apparent diffusion coefficient (ADC) value on diffusion-weighted imaging (DWI) and Gleason score of prostate cancer and percentage of tumor involvement on prostate core biopsy. MATERIALS AND METHODS We performed a retrospective study of 57 patients with biopsy-proven prostate cancer who underwent endorectal MRI...

Our aim was to study the level of interobserverconcordance in the Gleason scores of prostate needlebiopsy specimens reported at 1 institution. Aretrospective review of all prostate needle biopsyspecimens in which a diagnosis of adenocarcinoma wasmade during the year 2000 was conducted. Parametersevaluated included the Gleason score, Gleason gradesidentified, the perc...

Objective: To investigate the correlation between postoperative pathologic grade of prostate cancer (PC) and preoperative serum PSA as well as grade of biopsy specimens. Methods: The serum PSA and preoperative and postoperative Gleason scores of PC were retrospectively analyzed in 75 patients. Correlation between serum PSA and postoperative Gleason score was evaluated, and the Gleason score bef...

PURPOSE To investigate the role of low dose rate (LDR) brachytherapy-based multimodal therapy in high-risk prostate cancer (PCa) and analyze its optimal indications. MATERIALS AND METHODS We reviewed the records of 50 high-risk PCa patients [clinical stage ≥ T2c, prostate-specific antigen (PSA) >20 ng/mL, or biopsy Gleason score ≥ 8] who had undergone 125I LDR brachytherapy since April 2007. ...

INTRODUCTION Gleason score, which has a high interobserver variability, is used to classify prostate cancer. The most recent consensus valued the tertiary Gleason pattern and recommended its use in the final score of needle biopsies (modified Gleason score). This pattern is considered to be of high prognostic value in surgical specimens. This study emphasized the evaluation of the modified scor...

Introduction. To assess the performance of five previously described clinicopathological definitions of low-risk prostate cancer (PC). Materials and Methods. Men who underwent radical prostatectomy (RP) for clinical stage ≤T2, PSA <10 ng/mL, Gleason score <8 PC, diagnosed by transperineal template-guided saturation biopsy were included. The performance of five previously described criteria (i.e...

Purpose: To assess differentially methylated "landscapes" according to prostate cancer Gleason score (GS) andERGoncogene expression status, and to determine the extent of polycomb group (PcG) target gene involvement, we sought to assess the genome-wideDNAmethylation profile of prostate cancer according to Gleason score and ERG expression. Experimental Design:Genomic DNA from 39 prostate cancer ...