Cancer epidemiological research has a long and distinguished history and as we continue our work in ever expanding new fields, molecular or otherwise, it is perhaps worthwhile to take time out occasionally to ponder what lessons we can learn from the past. Many of the paradigms which are presently accorded respect in fact were hinted at by very early work and it is fitting that we take a look a...

Dynamical systems perspectives on emotion emphasize the importance of the regulatory interplay between brain, body and environment to adaptive behaviour. We suggest that a key facet of emotions, above all fear, consistent with this perspective lies in the allostatic regulation of constitutive/behavioural dynamics in terms of prediction and behavioural biases linking internal needs to external a...

The notion of internal models has become central to the study of visually guided reaching. Armed with this theoretical framework, researchers are gleaning insights into long-standing problems in the field, such as the ability to respond rapidly to changes in the location of a reach target and the fine control of the multi-joint dynamics of the arm. A key factor in these advances is our increase...

Distributed control protocols routinely have to operate oblivious of dynamic network information for scalability or complexity reasons. However, more informed protocols are likely to make more intelligent decisions. We argue that protocols can leverage dynamic congestion information without suffering the mentioned penalties. In this paper we show that routers can readily exchange congestion inf...

The revolutionary potential of massive open online courses (MOOCs) has been met with much skepticism, particularly in terms of the quality of learning offered. Believing that a focus on learning is more important than a focus on course completion rates, this position paper presents a pedagogical assessment of MOOCs using Chickering and Gamson's Seven Principles of Good Practice in Undergraduate...

BDNF (Brain derived neurotrophic factor) is a secretion protein and a member of the neurotrophin family of growth factors. Structural and functional characterization of BDNF Varanus komodoensis is of interest while its structure remains unknown. Thus, a homology molecular model of BDNF was constructed for gleaning possible structural insights. The model was compared with the structure of the ho...