ABSTRACT: Glanders is a disease caused by the bacterium Burkholderia mallei that primarily affects horses, mules and donkeys. The can cause lesions in skin, lungs several other organs. However, it often manifests as an asymptomatic disease. In Brazil, serological tests of high sensitivity specificity are used to assist detection antibodies against B. contribute control due mandatory euthanasia ...

We report the draft genome sequence of Mycobacterium farcinogenes NCTC 10955 (=DSM 43637(T)), a nontuberculosis species responsible for bovine farcy. The strain described here is composed of 6,139,893 bp, with a G+C content of 65.73%, and contains 5,816 protein-coding genes and 76 RNA genes.

Burkholderia mallei, the etiologic agent of glanders, are Category B select agents with biothreat potential, and yet effective therapeutic treatments are lacking. In this study, we showed that CpG administration increased survival, demonstrating protection in the murine glanders model. Bacterial recovery from infected lungs, liver and spleen was significantly reduced in CpG-treated animals as c...

Burkholderia mallei is a gram-negative obligate animal pathogen that causes glanders, highly contagious and potentially fatal disease of solipeds including horses, mules, donkeys. Humans are also susceptible, exposure can result in wide range clinical forms, i.e., subclinical infection, chronic forms with remission exacerbation, or acute lethal septicemia and/or pneumonia. Due to intrinsic anti...

glanders, caused by infection with the bacterium burkholderia mallei is a highly contagious and often fatal zoonotic disease of solipeds. it is an old disease, described as early as 400 bc by hippocrates and 330 bc by aristotlein the past, b. mallei was an important equine pathogen worldwide. its spread was facilitated by the use and transport of horses, especially when animals were housed unde...

Glanders and melioidosis are two infectious diseases that are caused by Burkholderia mallei and Burkholderia pseudomallei respectively. Infection may be acquired through direct skin contact with contaminated soil or water. Ingestion of such contaminated water or dust is another way of contamination. Glanders and melioidosis have both been studied for weaponisation in several countries in the pa...

Burkholderia mallei is an obligate mammalian pathogen that causes the zoonotic disease glanders. Two live attenuated B. mallei strains, a capsule mutant and a branched-chain amino acid auxotroph, were evaluated for use as vaccines against aerosol-initiated glanders in mice. Animals were aerogenically vaccinated and serum samples were obtained before aerosol challenge with a high-dose (>300 time...