نتایج جستجو برای: gk model

تعداد نتایج: 2106445  

2011
Jonathan Lou S. Esguerra Caroline Bolmeson Corrado M. Cilio Lena Eliasson

BACKGROUND The Goto-Kakizaki (GK) rat is a well-studied non-obese spontaneous type 2 diabetes (T2D) animal model characterized by impaired glucose-stimulated insulin secretion (GSIS) in the pancreatic beta cells. MicroRNAs (miRNAs) are short regulatory RNAs involved in many fundamental biological processes. We aim to identify miRNAs that are differentially-expressed in the pancreatic islets of ...

1993
Matthias Blau

We give a derivation of the Verlinde formula for the Gk WZW model from Chern-Simons theory, without taking recourse to CFT, by calculating explicitly the partition function ZΣ×S1 of Σ × S 1 with an arbitrary number of labelled punctures. By a suitable gauge choice, ZΣ×S1 is reduced to the partition function of an Abelian topological field theory on Σ (a deformation of non-Abelian BF and Yang-Mi...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
Christopher A Johnston Dustin S Whitney Brian F Volkman Chris Q Doe Kenneth E Prehoda

New protein functions can require complex sequence changes, but the minimal path is not well understood. The guanylate kinase enzyme (GK(enz)), which catalyzes phosphotransfer from ATP to GMP, evolved into the GK domain (GK(dom)), a protein-binding domain found in membrane associate guanylate kinases that function in mitotic spindle orientation and cell adhesion. Using an induced polarity assay...

Journal: :Journal of neurophysiology 1998
V S Sohal C L Cox J R Huguenard

In an earlier experimental study, intracellular recording suggested that cholecystokinin (CCK) suppresses a K+ conductance in thalamic reticular (RE) neurons, yet the reversal potential of the CCK response, revealed using voltage clamp, was hyperpolarized significantly relative to the K+ equilibrium potential. Here, biophysical models of RE neurons were developed and used to test whether suppre...

Journal: :American journal of physiology. Cell physiology 2012
Jin Hee Lee Thomas Palaia Louis Ragolia

Insulin resistance associated with Type 2 diabetes contributes to impaired vasorelaxation and therefore contributes to the enhanced incidence of hypertension observed in diabetes. In this study, we examined the role of insulin on the association of the myosin-binding subunit of myosin phosphatase (MYPT1) to myosin phosphatase Rho-interacting protein (MRIP), a relatively novel member of the myos...

Journal: :Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2015
A Alameddine Z Fajloun J Bourreau G Gauquelin-Koch M Yuan D Gauguier S Derbre A Ayer M A Custaud N Navasiolava

Many factors, including hyperglycemia, hypertension, obesity, dyslipidemia, and a sedentary lifestyle, contribute to a high prevalence of cardiovascular disease. Specific vascular impairment treatments in the context of diabetes and vascular risk need to be improved. Salidroside is the primary active component of Rhodiola rosea and has documented antioxidative, cardioprotective, and vasculoprot...

Journal: :Diabetes 2003
Helena C Murphy Gemma Regan Irina G Bogdarina Adrian J L Clark Richard A Iles Robert D Cohen Graham A Hitman Colin L Berry Zoe Coade Clive J Petry Shamus P Burns

Increased hepatic gluconeogenesis maintains glycemia during fasting and has been considered responsible for elevated hepatic glucose output in type 2 diabetes. Glucose derived periportally via gluconeogenesis is partially taken up perivenously in perfused liver but not in adult rats whose mothers were protein-restricted during gestation (MLP rats)-an environmental model of fetal programming of ...

2011
Kirsty S. Cullen Franz M. Matschinsky Loranne Agius Catherine Arden

OBJECTIVE The posttranslational regulation of glucokinase (GK) differs in hepatocytes and pancreatic β-cells. We tested the hypothesis that GK mutants that cause maturity-onset diabetes of the young (GK-MODY) show compromised activity and posttranslational regulation in β-cells. RESEARCH DESIGN AND METHODS Activity and protein expression of GK-MODY and persistent hyperinsulinemic hypoglycemia...

Journal: :The Journal of biological chemistry 2009
Rhonda A Newman Kenneth E Prehoda

Membrane-associated guanylate kinases (MAGUKs) regulate the formation and function of molecular assemblies at specialized regions of the membrane. Allosteric regulation of an intramolecular interaction between the Src homology 3 (SH3) and guanylate kinase (GK) domains of MAGUKs is thought to play a central role in regulating MAGUK function. Here we show that a mutant of the Drosophila MAGUK Dis...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید