نتایج جستجو برای: gja8
تعداد نتایج: 130 فیلتر نتایج به سال:
Cx50 (connexin50), a member of the α-family of gap junction proteins expressed in the lens of the eye, has been shown to be essential for normal lens development. In the present study, we identified a CaMBD [CaM (calmodulin)-binding domain] (residues 141-166) in the intracellular loop of Cx50. Elevations in intracellular Ca2+ concentration effected a 95% decline in gj (junctional conductance) o...
Previous studies have shown that chemical regulation of connexin43 (Cx43) depends on the presence of the carboxyl terminal (CT) domain. A particle-receptor (or "ball-and-chain") model has been proposed to explain the mechanism of gating. We tested whether the CT region behaved as a functional domain for other members of the connexin family. The pH sensitivity of wild-type and Ct-truncated conne...
Gap junction (GJ) channels provide direct passage for ions and small molecules to be exchanged between neighbouring cells and are crucial for many physiological processes. GJ channels can be gated by transjunctional voltage (known as Vj-gating) and display a wide range of unitary channel conductance (γj), yet the domains responsible for Vj-gating and γj are not fully clear. The first extracellu...
Introduction Variants in the two lens-expressed gap junction genes GJA3 and GJA8 are among most common causes of inherited pediatric cataract. These alone account for up to 18% cases, second only crystallin gene family.Areas covered All published cataract-associated variants were reviewed a role Autosomal dominant inheritance was frequently reported, alongside instances reduced penetrance autos...
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