Pyoderma gangrenosum (PG) is a neutrophilic dermatosis of unknown origin. Clinically it starts with a pustule, nodule or bulla that rapidly progresses and turns into a painful ulcer with raised, undermined borders. The etiopathogenesis of PG remains unknown. However it is frequently associated with systemic diseases such as inflammatory bowel disease (IBD), haematological disorders or arthritis...

Richard J. Miller,1 William Rostene,2 Emanuelle Apartis,2,3 Ghazal Banisadr,1 Knut Biber,4 Erin D. Milligan,5 Fletcher A. White,6 and Ji Zhang7 1Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60611, 2Inserm, Unité Mixte 732, Université Pierre et Marie Curie Paris 06, Hôpital Saint-Antoine, 75016 Paris, France, 3Department...

Fibronectin (FN) mRNA levels increased when quiescent cells (serum starved) were stimulated to undergo the G0/G1 transition by the addition of 20% given fetal calf serum to the media. The 5'-flanking region of the FN gene (position +69 to -510 base pairs (bp] was fused to the coding region of the chloramphenicol acetyltransferase (CAT), and the fusion gene was used in transfection assays. Expre...