The eukaryotic cell encounters more than one million various kinds of DNA lesions per day. The nucleotide excision repair (NER) pathway is one of the most important repair mechanisms that removes a wide spectrum of different DNA lesions. NER operates through two sub pathways: global genome repair (GGR) and transcription-coupled repair (TCR). GGR repairs the DNA damage throughout the entire geno...

active queue management (aqm) plays an important role in the internet congestion control. it tries to enhance congestion control, and to achieve tradeoff between bottleneck utilization and delay. random early detection (red) is the most popular active queue management algorithm that has been implemented in the in internet routers and is trying to supply low delay and low packet loss. red algori...

<abstract><p>We present a novel direct integral pseudospectral (PS) method (a IPS method) for solving class of continuous-time infinite-horizon optimal control problems (IHOCs). The transforms the IHOCs into finite-horizon in their forms by means certain parametric mappings, which are then approximated finite-dimensional nonlinear programming (NLPs) through rational collocations bas...

BACKGROUND The causative link between UV exposure and melanoma development is well known, however the mechanistic relationship remains incompletely characterised. UVA and UVB components of sunlight are implicated in melanomagenesis; however the majority of studies have focused on the effects of UVB and UVC light. Interestingly, melanoma tumour sequencing has revealed an overrepresentation of mu...

Dentro de la raza Chalqueño maíz se pueden reconocer diferentes grupos genéticos regionales (GGR) principalmente con base en su origen geográfico y características grano. El objetivo esta investigación fue determinar el comportamiento agronómico esos GGR heterosis, así como las relaciones entre heterosis divergencia genética. Cuarenta nueve poblaciones nativas sobresalientes Chalqueño, agrupada...

GGR News: we hear that . . . , by David Garfinkle . . . . . . . . . . . . . . . . . . . . . 4 News from the GRG Society, by Abhay Ashtekar . . . . . . . . . . . . . . 5 LIGO/GEO/Virgo work together, by Peter Saulson . . . . . . . . . . . . . 8 GWIC Ten Years on , by Stan Whitcomb . . . . . . . . . . . . . . . . . 10 Research Briefs: Quasi-local energy, by Bjoern S. Schmekel . . . . . . . . . . ...

In Saccharomyces cerevisiae the Rad4-Rad23 complex is involved in initial damage recognition and responsible for recruiting the other NER proteins to the site of the lesion. The Rad4-Rad23 complex is essential for both NER subpathways, Transcription Coupled Repair (TCR) and Global Genome Repair (GGR). Previously, we reported on the role of the Rad4 homologue YDR314C in NER. YDR314C is essential...

This paper provides steady state queue-size distribution for a G/G/1 queue by using principle of maximum entropy. For this purpose we have used average queue length and normalizing condition as constraints to derive queue-size distribution. Our results give good approximation as demonstrated by taking a numerical illustration. In particular case when square coefficient of variation of inter-arr...

in this paper, we study the network location problem for two congestible facilities, considering impatient customers. we suppose that when a customer arrives his/her corresponding facility and faces a queue with the size more than a predetermined threshold, the customer decides not to join the queue but to go to the closest facility to current facility. in the second facility, if the queue size...

Plants use the energy in sunlight for photosynthesis, but as a consequence are exposed to the toxic effect of UV radiation especially on DNA. The UV-induced lesions on DNA affect both transcription and replication and can also have mutagenic consequences. Here we investigated the regulation and the function of the recently described CUL4-DDB1-DDB2 E3 ligase in the maintenance of genome integrit...