Thiocoraline (1) is a new antitumor antibiotic isolated from the mycelium of Micromonospora sp. L-13-ACM2-092. Its structure was elucidated to be a novel cyclic thiodepsipeptide on the basis of spectroscopic methods.

BACKGROUND Numerous frailty screening instruments are available, but their applicability for identifying frailty in patients with end-stage renal disease (ESRD) is unknown. We aimed to investigate the diagnostic accuracy of three instruments used for frailty screening in an ESRD population. METHODS The study was conducted in 2013 in a teaching hospital in The Netherlands and included patients...

Aging is significantly associated with the development of comorbid chronic conditions. These conditions indicate the use of multiple medications, and are often warranted by clinical guidelines. The aim of the present study was to evaluate medication appropriateness and frailty among Malaysian aged care home residents with chronic disease. The participants were 202 elderly (≥65 years) individual...

The human cognitive system is severely limited in the amount of information it can process simultaneously. When two tasks are presented within a short stimulus-onset-asynchrony (SOA), reaction time of each task, especially task 2, is dramatically delayed. Previous studies have shown that such delay is accompanied by increased activation in the right inferior frontal gyrus (GFi). In this study, ...

Global precipitation isoscapes based on the Global Network for Isotopes in Precipitation (GNIP) network are an important toolset that aid our understanding of global hydrologic cycles. Although the GNIP database is instrumental in developing global isoscapes, data coverage in some regions of hydrological interest (e.g., drylands) is low or non-existent thus the accuracy and relevance of global ...

The Competitive State Anxiety Inventory-2 Revised (CSAI-2R), is one of the most frequently used instruments in the evaluation of situational anxiety in sports competition. Objectives: The objective of this study was to validate the Tunisian version based on the French version of the Competitive State Anxiety Inventory-2 Revised (CSAI-2R), including the direction and the frequency scales. Method...

We used functional magnetic resonance imaging in 18 normal volunteers to determine whether there is separate representation of syntactic, semantic, and verbal working memory processing in the left inferior frontal gyrus (GFi). We compared a sentence comprehension task with a short-term memory maintenance task to identify syntactic and semantic processing regions. To investigate the effects of s...

After rearrangement of the T-cell receptor (TCR) beta-locus, early CD4(-)/CD8(-) double negative (DN) thymic T-cells undergo a process termed 'beta-selection' that allows the preferential expansion of cells with a functional TCR beta-chain. This process leads to the formation of a rapidly cycling subset of DN cells that subsequently develop into CD4(+)/CD8(+) double positive (DP) cells. Using t...