Hyperglycemia during pregnancy leads to fatal maternal and perinatal outcomes. Gestational diabetes mellitus (GDM) is diagnosed by 75 grams oral glucose tolerance test at 24-28 weeks of gestational age as insulin resistance increases the second trimester. Increased prevalence mellitus, sedentary lifestyle, Family history DM predisposes women, particularly Indian women develop GDM. Existence mul...

Impaired glucose tolerance has several adverse effects on growing fetus. In this study we evaluated the effect of excessive weight gain during pregnancy on the risk of glucose intolerance in pregnant women. A case-control study was conducted through which the glucose tolerance status after 100 gram oral glucose intake was compared between 60 pregnant women with maximum 10 weeks of gestation and...

Recent studies show that higher blood glucose values after a 75 g oral glucose tolerance test in pregnancy are associated with higher rates of perinatal and maternal complications. Treatment of gestational diabetes mellitus (hyperglycaemia in pregnancy) reduces the risk of complications. Gestational diabetes mellitus is an asymptomatic condition. Screening is the only strategy for diagnosing th...

It is unknown if high prolactin levels during pregnancy contribute to the development of gestational diabetes. We hypothesized that higher prolactin levels are associated with reduced glucose tolerance, as determined by higher 2-h glucose level from an oral glucose tolerance test in pregnancy. The 75-g oral glucose tolerance test was carried out at 28 weeks of gestation in 69 participants. A mu...

BACKGROUND The delivery of excess maternal nutrients to the fetus is known to increase the risk of macrosomia, even among infants of women without gestational diabetes mellitus. With the current obesity epidemic, maternal adiposity and its associated effects on circulating adipokines and inflammatory proteins may now have a greater impact on fetal growth. We sought to evaluate the independent e...

BACKGROUND The best method of screening for gestational diabetes (GDM) remains unsettled. The 50-g glucose challenge test (GCT) is used in a two-stage screening process but its best threshold value can vary according to population. AIMS To evaluate the role of risk factors in conjunction with GCT and to determine an appropriate threshold for the one-hour venous plasma glucose with the GCT. ...

BACKGROUND/AIMS This study was conducted to examine the relationship between family history of type 2 diabetes (T2DM) and risk of developing gestational diabetes mellitus (GDM) in Korean women. METHODS We performed a 100-g oral glucose tolerance test in 858 pregnant women who had abnormal glucose tolerance in 50-g oral glucose challenge. In addition, we reviewed the incidence of T2DM in the p...