The adult ovarian surface epithelium has already been proposed as a source of stem cells and germinal cells in the literature, therefore it has been termed the "germinal epithelium". At present more studies have confirmed the presence of stem cells expressing markers of pluripotency in adult mammalian ovaries, including humans. The aim of this study was to isolate a population of stem cells, ba...

Background: Busulfan is a chemotherapy drug that is widely used for cancer treatment. However, administration of busulfan to male patients with malignant diseases may cause temporary or permanent sterility. Therefore, research into drugs or Materials to reduce the side effects of busulfan on the male reproductive system is necessary. In the present study the protective effects of L-carnitine an...

Background: Mesenchymal stem cells (MSCs) can be used to treat premature ovarian failure (POF). Different methods have already been applied to detect MSCs in tissues. This study aimed to investigate the quantitative distribution of CM-DiI-labeled human umbilical cord vein MSCs (hUCV-MSCs) in different regions of the ovarian tissue of the cyclophosphamide ( CTX )-induced POF in mice. Methods: Ad...

background: phthalate esters have been shown to cause reproductive toxicity in both developing and adult animals. objective: this study was designed to assess long-term effects of maternal exposure to di (2-ethylhexyl) phthalate (dehp) on reproductive ability of both neonatal and adult male offspring. materials and methods: 60 female rats randomly divided in four equal groups; vehicle control a...

Background: Surgical castration of male piglets is frequently performed to prevent development of an unpleasant taste and flavor in meat of mature males, called boar taint. Disadvantages of this method are primarily related to the lower feed efficiency of surgically castrated male pigs, production of less lean meat and more fat on the carcasses than boars, as well as ethical issues associated w...

The aspartic proteinase cathepsin D was purified from human spleen and localised in various formalin fixed paraffin embedded human tissues using the peroxidase-antiperoxidase (PAP) technique. Cathepsin D was shown not only in macrophages but also in other connective tissue cells, and in epithelium. It was present in spleen (littoral cells and cells within Malpighian bodies), liver (hepatocytes ...

Solid ovarian tumors of all types are very uncom mon in the lower animals, and teratomas of the ovary are exceedingly rare. In @,000autopsies on mice, Slye, Holmes, and Wells (1@) found only 46 with solid tumors of the ovary, and of these only one was a teratoma. Many of the mice they cx amined, moreover, were from stock having a high incidence of tumor formation. The present paper reports the ...

background: busulfan (bus) is a chemotherapy drug that is widely used for cancer treatment. however, administration of busulfan may cause temporary or permanent sterility in male patients. therefore, reduction of this side is necessary. objective: evaluation of the protective effects of l-carnitine and testis homogenized tissue (tht) on sperm parameters and the testis structure after busulfan t...