From the aerial roots of the medicinal plant Geranium sanguineum L. a polyphenol-rich extract with strong anti-influenza activity has been isolated. To investigate its active fractions, the extract was partitioned by solvents with increasing polarity. The n-BuOH fraction contained the majority of the in vitro antiviral activity; the EtOAc fraction was the most effective one in vivo. A bioassay-...

BACKGROUND Geranium sibiricum L. has been used as a medicinal plant to treat diarrhea, bacterial infection, and cancer in Bulgaria, Peru, and Korea. However, its hair growth-promoting effect was not investigated so far. This study examined the effects of Geranium sibiricum L. extract (GSE) on hair growth, using in vitro and in vivo models. METHODS Antioxidant, proliferation and migration assa...

A number of supplements are now available which are sold as fat burners or pre-workout boosters and contain stimulants which are banned in sport. Many contain methylhexaneamine under one of many pseudonyms including Geranamine, geranium oil or extract, or a number of chemical names such as 1,3-dimethylpentylamine. This has resulted in many athletes returning an adverse finding and having sancti...

Key message. The success of interspecific hybridization in hardy geranium (Geranium sp.) can be predicted by considering the genetic distance between parental genotypes and using logistic regression model developed this study. Hardy is a popular ornamental plant known for its architecture, hardiness, prolonged flowering, diverse colors leaves flowers. In breeding, pursuit novel trait combinatio...

Ralstonia solanacearum (biovar 2, race 3) is a soil and water-borne pathogen that causes serious diseases in several solanaceous hosts. It can also infect geranium plants, posing an important threat to their culture when latently infected cuttings are imported from countries where the pathogen is endemic. R. solanacearum can be present in very low numbers in asymptomatic geranium cuttings, and/...

The objective was to determine the regulatory dynamic of Nrf2 during liver regeneration and the administration of EtOH and/or the G. schiedeanum extract. Male Wistar rats weighing 200-230 g were subjected to a 70% partial hepatectomy; they were then divided into three groups (groups 1-3). During the experiment, animals in Group 1 drank only water. The other two groups (2-3) received an intragas...

The combined virus-inhibitory effects of a proteinaceous protease inhibitor, produced by Streptomyces sp. 225b (BF), rimantadine hydrochloride (Rim), ε-aminocaproic acid (ACA) and a polyphenol extract from Geranium sanguineum L. (PC) have been investigated on the reproduction of influenza virus A/Germany/34, strain Rostock (H7N1) in MDCK cell cultures. The simultaneous application of BF and PC,...