OBJECTIVES To compare genotypic and phenotypic HIV-1 drug resistance assays. METHODS Protease inhibitor (PI) susceptibility was phenotypically analysed in HIV-1 isolates and recombinant viruses expressing proteases from viral isolates. Two genotypic interpretation methods were carried out in parallel. RESULTS Entirely concordant resistance levels were shown in 5/10 (50%) highly active anti-...

Theory predicts, and recent empirical studies have shown, that the diversity of plant species determines the diversity of associated herbivores and mediates ecosystem processes, such as aboveground net primary productivity (ANPP). However, an often-overlooked component of plant diversity, namely population genotypic diversity, may also have wide-ranging effects on community structure and ecosys...

Genes encode components of coevolved and interconnected networks. The effect of genotype on phenotype therefore depends on genotypic context through gene interactions known as epistasis. Epistasis is important in predicting phenotype from genotype for an individual. It is also examined in population studies to identify genetic risk factors in complex traits and to predict evolution under select...

Using diploidy and dominance is one method to enhance the performance of genetic algorithms in dynamic environments. For diploidy genetic algorithms, there are two key design factors: the cardinality of genotypic alleles and the uncertainty in the dominance scheme. This paper investigates the effect of these two factors on the performance of diploidy genetic algorithms in dynamic environments. ...

to investigate the genotypic and phenotypic relationship between characteristics affecting tomato fruit weights, eleven tomato lines were compared in a rcb design with three replications. the anova showed that the difference among lines was significant for all characteristics. there was a significant phenotypic and genotypic correlations between fruit weight and most of the characteristics. the...

Genotypic diversity of total phenolics, flavonoid content and antioxidant capacity in the USDA rice mini-core collection was analyzed. Wide genotypic variation found ABTS capacity. Genome-wide association mapping between three traits 155 SSR markers conducted using Q + K model which takes both population structure (Q) relative kinship (K) into consideration. A 23 marker trait were identified wi...

BACKGROUND/AIMS Clinical characteristics of patients with chronic hepatitis B (CHB) who developed genotypic resistance to entecavir (ETV) were compared to those without resistance. METHODS Two hundred fifty eight CHB patients who underwent ETV treatment in our institution from July 2007 to May 2013 were included. RESULTS Eight (3.1%) patients developed genotypic resistance to ETV during the...

Genetic diversity within key species can play an important role in the functioning of entire communities. However, the extent to which different dimensions of diversity (e.g., the number of genotypes vs. the extent of genetic differentiation among those genotypes) best predicts functioning is unknown and may yield clues into the different mechanisms underlying diversity effects. We explicitly t...

BACKGROUND A tropism test is required before administration of the antiretroviral drug maraviroc. However, plasma RNA testing is not possible in patients with undetectable plasma viral loads. Here we assess genotypic testing of cellular human immunodeficiency virus (HIV) DNA from peripheral blood mononuclear cells (PBMCs) to predict virologic responses in treatment-experienced patients beginnin...