نتایج جستجو برای: genome instability

تعداد نتایج: 315656  

Journal: :Cold Spring Harbor Symposia on Quantitative Biology 2017

2013
Scott Newman Karen D. Howarth Chris D. Greenman Graham R. Bignell Simon Tavaré Paul A. W. Edwards

Many tumors have highly rearranged genomes, but a major unknown is the relative importance and timing of genome rearrangements compared to sequence-level mutation. Chromosome instability might arise early, be a late event contributing little to cancer development, or happen as a single catastrophic event. Another unknown is which of the point mutations and rearrangements are selected. To addres...

Journal: :Proceedings of the National Academy of Sciences 2012

Journal: :Asian Pacific Journal of Cancer Prevention 2012

Journal: :The Plant cell 2011
Youli Yao Cristian H Danna Franz J Zemp Viktor Titov Ozan Nazim Ciftci Roman Przybylski Frederick M Ausubel Igor Kovalchuk

We have previously shown that local exposure of plants to stress results in a systemic increase in genome instability. Here, we show that UV-C-irradiated plants produce a volatile signal that triggers an increase in genome instability in neighboring nonirradiated Arabidopsis thaliana plants. This volatile signal is interspecific, as UV-C-irradiated Arabidopsis plants transmit genome destabiliza...

Journal: :Science 2002
Richard D Kolodner Christopher D Putnam Kyungjae Myung

Most human cancer cells show signs of genome instability, ranging from elevated mutation rates to gross chromosomal rearrangements and alterations in chromosome number. Little is known about the molecular mechanisms that generate this instability or how it is suppressed in normal cells. Recent studies of the yeast Saccharomyces cerevisiae have begun to uncover the extensive and redundant pathwa...

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