Gut microbes are immunologically tolerated in the gastrointestinal tract but trigger aggressive immune responses upon translocation across gut barrier. Although oral tolerance, a physiological process that dampens to food proteins and commensal microbiota, remains poorly defined, significant progress was made during after Human Immunodeficiency Virus epidemic 1980s discovery of regulatory T cel...

New tumor-targeted biological approaches to the therapy of childhood solid tumors have the promise to improve the survival of children with advanced or refractory malignancy with less acute and long term toxicity. The challenge that remains is still similar to that with chemotherapy: identifying metabolic and genetic pathways and targets that are sufficiently different or amplified in the malig...

MANY common disorders, including schizophrenia ers are affected, however, and the probable mode of disease inheritance is dominant with reduced peneand bipolar affective disorder, are highly heritatrance. That is to say inheritance of the translocation ble, yet do not exhibit simple inheritance patterns. Indiconfers a genetic predisposition to develop psychiatric vidual risk is usually attribut...

Translocation, the intentional release of captive-propagated and/or wild-caught animals into the wild in an attempt to establish, reestablish, or augment a population, is a commonly used approach to species conservation. Despite the frequent mention of translocation as an aid in threatened or endangered species recovery plans, translocations have resulted in the establishment of few sustainable...

Robertsonian translocations (RBT) are associated with an increased risk of aneuploidy. Single RBT carriers are the most common balanced rearrangement among the carrier couples with the history of spontaneous abortion. However, double Robertsonian translocations (DRBT), in which two balanced RBT occur simultaneously, are an extremely rare condition. A 9-year-old mentally normal girl with mu...

Preimplantation genetic diagnosis (PGD) is gradually widely used in prevention of gene diseases and chromosomal abnormalities. Much improvement has been achieved in biopsy technique and molecular diagnosis. Blastocyst biopsy can increase diagnostic accuracy and reduce allele dropout. It is cost-effective and currently plays an important role. Whole genome amplification permits subsequent indivi...

phenotypically normal females with secondary amenorrhea and translocation between Xq and Yq. To the best of our knowledge, the detection of Xq;Yq translocation at prenatal diagnosis has not been reported. Herein, we report the prenatal diagnosis of a de novo unbal­ anced Xq;Yq translocation for the first time and discuss issues in genetic counseling to be given to patients with this particular ...

this case report presents a coincidence of trisomy 18 and balanced robertsonian translocation (13;14). aneuploidy was suspected based on anomalies detected in ultrasound scan and confirmed with karyotype. in a 31 years-old healthy woman with a history of one miscarriage, second trimester ultrasound scan reported iugr (<3rd percentile) with normal amniotic fluid, bilateral choroid plexus cysts, ...

This paper reviews the advantages of the yeast Yarrowia lipolytica as a tool in the study of protein secretion. Work has been focused on the early steps leading the polypeptide, from the cytoplasmic ribosomes where it is synthesized, to the lumen of the endoplasmic reticulum. Using a thermosensitive allele of the 7SL RNA, the first in vivo evidence for a co-translational translocation was shown...