Throughout the C. elegans sequencing project Genefinder was the primary protein-coding gene prediction program. These initial predictions were manually reviewed by curators as part of a "first-pass annotation" and are actively curated by WormBase staff using a variety of data and information. In the WormBase data release WS133 there are 22,227 protein-coding gene, including 2,575 alternatively-...

The Wilms Tumour 1 ( WT1) gene is a complex gene which was originally linked to suppression of cancer in kidneys. Studies of WT1-knockout mice confirmed the important role of WT1 in the pathogenesis of Wilms’ tumour, a tumour which accounts for 95% of all childhood renal tumours. In such cases, the WT1 gene acts as a tumoursuppressor gene. Subsequent research has shown that the WT1 gene in many...

The collagens of vertebrates may be divided into three groups according to chain size and whether or not the helical domains are continuous. Present evidence suggests that, at least within one of these groups, similarity between collagens is reflected in the organization of the genes that encode them. Early evidence suggested that collagen genes evolved on the basis of exons which are multiples...

It is generally recognized that the genes or inheritable characters of all organisms, with the possible exception of the bacteria, are localized in the cell nucleus, and, more specifically, in the chromosomes. The intrinsic relationship between the genes and the chromosomal nucleoproteins is supported by cytochemical as well as by photochemical evidence: Desoxyribonucleoproteins represent the q...

understanding still is. Indeed, there is an implicit comparison of the art of perfumery to the esthetic achievements which delight the other senses. The author proceeds to address a number of other topics, which include smiling, laughing, singing, pain, haptics (the sense of touch), pictorial interpretation, and speech disorders. For each, he draws on a wealth of historical examples to illustra...

With advances in genetic science, the dynamic structure of eukaryotic genome is considered as basis of gene expression regulation. Long-distance communication between regulatory elements and target promoters is critical and the mechanisms responsible for this connection are just starting to emerge. Chromatin insulators are key determinants of proper gene regulation and precise organization of c...

background: causing site direct mutation can be one of the efficient methods to evaluate the characteristics and properties of various genes. brucellosis is the most common zoonotic infectious disease that would cause great economic losses. thus, recognition of pathogenic and immunogenic factors in the genus brucella can lead to control this health problem. objectives: considering the importanc...

introduction: failure of human body tissue and organs is believed to be one of the most important health problems all over the world. the great challenge for tissue engineers is to optimize suitable systems to separate, proliferate and differentiate the cells so that they can set out to create tissue by a harmonic 3-d growth. therefore, the tissue engineers must provide an environment like the ...