Objective: Phenolic compounds have been considered inhibitors of various cancers. Material and Methods: In this study, caffeic acid and gallic acid were appraised for their possible effects on apoptotic genes expression in a breast cancer cell line in vitro. We also evaluated ligand interaction and ligand binding with estrogen receptor alpha by m...

combination therapy with clomiphene citrate plus gonadotropin (clomiphene citrate plus hmg) in induction ovulation reduce the gonadotropins dose but antiestrogenic effect of c.c. can decrease pregnancy rate. in a randomized clinical trial we compared 3 treatment protocol for induction ovulation and intra uterine insemination (i/o plus iui) in women with infertility history more than one year, n...

Introduction: Cervical cancer is the third most common tumor among women. Surgery, radiotherapy, and chemotherapy are common treatments, however high stage tumors have frequently poor prognosis. Nowadays, the epigenetic reversion introduced as an efficient strategy of treatment of cervical cancer. In the process, inhibitors of DNA methyltransferase (DNMT) induce re-expression of tumor suppresso...

   Background and Objective: Gliomas are the most common primary brain tumors. Despite therapeutic advances, the majority of gliomas do not respond to either chemo or radiotherapy. CD117, the gene product of c-kit has been expressed in cells of glial tumors. Because gastrointestinal stromal tumors (GISTs) that express CD117 respond dramatically to treatment with tyrosine kinase inhibitors, ide...

Abstract Background Our previous study shows that LINC01278 inhibits the malignant proliferation and invasion of papillary thyroid carcinoma (PTC) cells by regulating miR-376c-3p/DNM3 axis. However, regulation mechanism expression in PTC is still unclear. Methods The luciferase reporter ChIP assays were used to confirm binding LEF-1 putative promoter site gene. RNA immunoprecipitation pulldown ...

Abstract In this work, we are reporting that “Shock and Kill”, a therapeutic approach designed to eliminate latent HIV from cell reservoirs, is extrapolatable cancer therapy. This based on the observation malignant cells express spectrum of human endogenous retroviral elements (HERVs) which can be transcriptionally boosted by HDAC inhibitors. The endoretroviral gene HERV-V2 codes for an envelop...

Quorum sensing (QS) is a process that enables bacteria to communicate using secreted small pheromone-like signaling molecules called autoinducers (AIs). This population of regulate gene expression collectively. These quorum systems regulates biofilm formation, virulence factors expression, bioluminescence, motility patterns, exopolysaccharide production, antifungal or antibiotic endoglucanase p...

Infertility as a vital process in human reproduction involves many couples worldwide. Although many genetic causes of infertility are known, the genetic basis of infertility in men is largely unknown. Therefore, the identification of genetic biomarkers in this field is important and genetic polymorphisms in key genes of the spermatogenesis pathway can be valuable biomarkers in this field. Gene'...