نتایج جستجو برای: gene expression il 1b
تعداد نتایج: 1705519 فیلتر نتایج به سال:
Introduction & Objective: Interleukine-1 receptor antagonist (IL-1RA) is a powerful anti-inflammatory cytokine which limits the biological effects of IL-1. Due to structural similarity between IL-1 and its antagonist, IL-1RA competitively binds to IL-1 receptor which leads to no signal transduction. Therefore , it is applied in the treatment of patients with inflammatory diseases such as Rheu...
BACKGROUND Chlamydia trachomatis infections have been associated with tubal pathology. However, not all C.trachomatis-infected women actually develop tubal pathology. Recently, host genetic factors such as the interleukin-1 gene cluster have been linked to inflammatory and infectious diseases. METHODS Dutch Caucasian women were investigated for (i) the role of interleukin-1B (IL-1B) and inter...
introduction: multiple sclerosis is a chronic inflammatory disease of central nervous system. the etiology of ms is slightly known, but genetic and environmental factors are reported. vitamin d regulates gene expression and affects target cell functions. the aim of this study was to investigate the expression variation of il-2 and il-4 genes under vitamin d supplementation in patients with mult...
background: this study was designed to evaluate whether or not t. gondii and its derivatives can change the gene expression level of il-10 in murine leukocytes in vivo. methods: fifty balb/c mice were divided into 5 groups, four of which received the excretory/secretory product (esp) from cell culture medium, the esp from cell free medium, the toxoplasma lysate product (tlp) and the active ta...
Introduction: Multiple sclerosis is a chronic inflammatory disease of central nervous system. The etiology of MS is slightly known, but genetic and environmental factors are reported. Vitamin D regulates gene expression and affects target cell functions. The aim of this study was to investigate the expression variation of IL-2 and IL-4 genes under vitamin D supplementation in patients with mult...
objective(s):with regard to pharmacological effects of carvacrol on the respiratory system, its effect on cytokines genes expression in splenocytes of asthmatic mice was examined in this study. materials and methods:splenocytes were isolated from non-sensitized (control group), sensitized mice to ovalbumin (ova) (group s), and s animals treated with dexamethasone, and three concentrations of ca...
Background: The purpose of this study was to investigate the effect of concurrent training on pre-inflammatory (IL-1β, TNF-α) and anti-inflammatory (IL-10) cytokines gene expression in women with type2 diabetes. Methods: 18-patients (age30-38, >130 glycemic index) were selected, randomly, and divided into control (n=6) the concurrent training(diabetes, n=6) and the concurrent training (healthy...
Schroeder, Rebecca A., Charles Cai, and Paul C. Kuo. Endotoxin-mediated nitric oxide synthesis inhibits IL-1b gene transcription in ANA-1 murine macrophages. Am. J. Physiol. 277 (Cell Physiol. 46): C523–C530, 1999.—On the basis of previous work demonstrating nitric oxide (NO)mediated inhibition of nuclear factor-kB (NF-kB) DNA binding, we hypothesized that NO downregulates NF-kB-dependent inter...
The aim of this study was to identify, in cultured human cervical ®broblasts, the mechanisms by which interleukin (IL)-1b induces the synthesis of glycosaminoglycans (GAG) and to explore the putative role of prostaglandin E2 (PGE2) in this process. Exposure of the cells for 24 h to IL-1b induced a signi®cant (P < 0.05) dose-dependent increase in GAG synthesis. IL-1b (1 ng/ ml) induced the expre...
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