نتایج جستجو برای: gene disruption

تعداد نتایج: 1185457  

Journal: :Journal of Biological Chemistry 1999

Journal: :Journal of Biological Chemistry 1996

A. Khoshdel A. Movafagh A. Sayad K. Amini K. Majidzadeh-A M. A. Broumand M. D. Omrani M. Yari R. Mirfakhraie

Genome-Wide Association Studies (GWAS) have identified genetic variants contributing to the risk of cardiovascular disease (CVD) at the chromosome 9p21 locus. The chromosome 9p21 is an important susceptibility locus for several multifactorial diseases like ischemic stroke, aortic aneurysm, type 2 diabetes mellitus and coronary artery disease (CAD). F7 gene because of its role in activating the ...

Journal: :Journal of applied physiology 2010
Madelene Ericsson Cecilie Sjåland Kristin B Andersson Ivar Sjaastad Geir Christensen Ole M Sejersted Øyvind Ellingsen

In the heart, function of the sarco(endo)plasmic Ca(2+)-ATPase (SERCA2) is closely linked to contractility, cardiac function, and aerobic fitness. SERCA2 function can be increased by high-intensity interval training, whereas reduced SERCA2 abundance is associated with impaired cardiac function. The working hypothesis was, therefore, that exercise training before cardiomyocyte-specific disruptio...

Journal: :Applied and environmental microbiology 1993
T S Wu J E Linz

Functional disruption of the gene encoding nitrate reductase (niaD) in Aspergillus parasiticus was conducted by two strategies, one-step gene replacement and the integrative disruption. Plasmid pPN-1, in which an internal DNA fragment of the niaD gene was replaced by a functional gene encoding orotidine monophosphate decarboxylase (pyrG), was constructed. Plasmid pPN-1 was introduced in linear ...

Almadani N Borjian Boroujeni P, Gourabi H Sadighi gilani M Sarkardeh H, Totonchi M

Background: Thousands of genes are involved in spermatogenesis. Alterations in any of these genes could lead to male infertility. Moloney leukemia virus 10-Like 1 (Mov10l1) gene is one of the genes that are expressed specifically in germ cells. Genetic disruption of this gene in mouse stops spermatogenesis during Meiosis I and causes azoospermia. Materials and Methods: In this study, the geneti...

Journal: :Yeast 2002
Robert J D Reid Ivana Sunjevaric Mehdi Keddache Rodney Rothstein

Gene disruptions are a vital tool for understanding Saccharomyces cerevisiae gene function. An arrayed library of gene disruption strains has been produced by a consortium of yeast laboratories; however their use is limited to a single genetic background. Since the yeast research community works with several different strain backgrounds, disruption libraries in other common laboratory strains a...

Journal: :Bioinformatics 2002
Kimmo Palin Esko Ukkonen Alvis Brazma Jaak Vilo

MOTIVATION Finding putative transcription factor binding sites in the upstream sequences of similarly expressed genes has recently become a subject of intensive studies. In this paper we investigate how much gene expression regulation can be attributed to the presence of various binding sites in the gene promoters by correlating the binding sites and the changes in gene expression resulting fro...

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