Background: KDM3A is a key epigenetic regulator that is expressed in the testis and is required for packaging and condensation of sperm chromatin. To this point, the association of the KDM3A gene and infertility has not been studied in human. The aim of this study was to screen any new mutation in KDM3A gene to explore more details of human male infertility. Methods: In this work, 150 infertile...

abstract: fifteen non-aflatoxigenic strains of aspergillus flavus, represent a wide range of geographic regions of iran (six provinces include fars, ardebil, guilan, golestan, kerman and semnan) and vegetative compatibility groups (vcgs), were collected from corn (zea mays l.), peanut (arachis hypogaea l.) and pistachio (pistachia vera l.) soils and kernels, were screened for the presence of af...

Mutations in the connexin 26 (Cx26) gene at the DFNB1 locus on chromosome 13q12 are associated with autosomal recessive non-syndromic hearing loss (ARNSHL). There are many known mutations in this gene that cause hearing loss. A single frameshift, at position 35 (35delG) accounts for 50% of mutations in the Caucasian population with carrier frequencies of 1.5-2.5%. In this study we investigated ...

early-onset, generalized primary torsion dystonia (ptd) is an autosomal dominant disorder, characterized by involuntary movements and abnormal postures. the majority of cases are caused by a 3-bp deletion (gag deletion at position 946) in the dyt1 gene on chromosome 9q34 that allows for specific genetic testing. forty eight patients with early onset primary torsion dystonia were screened for th...

breast cancer (bc) is considered as one of the most important causes of death worldwide. previous studies showed that apolipoprotein b mrna- editing catalytic polypeptide-like 3 (apobec3) gene deletion significantly increased the risk of bc risk in chinese and european women. the present study aimed to assess the possible impact of apobec3 deletion and the risk of bc in a sample of iranian popu...

Abstract Background Thalassemia is common in the Iranian population, and it must be considered in the differential diagnosis of the microcytic hypochromic anemia. The molecular analysis of β-thalassemia is necessary for prenatal molecular diagnosis. Α-thalassemia caused by loss of function of either one of the two duplicated α-globin genes or in less frequent non deletion mutations mostly loc...

objectives: strr is a putative pathway specific regulator of streptomycin production in streptomyces griseus. because of finding new spo0j domain in strr by bioinformatics methods, the purpose of this study was to suggest another role for strr gene. this domain can be seen in proteins that are involved in initiation of sporulation and normal chromosome partitioning. so, 51 bps of strr in accord...

Fifteen non-aflatoxigenic strains of Aspergillus flavus, represent a wide range of geographic regions of Iran (six provinces include Fars, Ardebil, Guilan, Golestan, Kerman and Semnan) and vegetative compatibility groups (VCGs), were collected from corn (Zea mays L.), peanut (Arachis hypogaea L.) and pistachio (Pistachia vera L.) soils and kernels, were screened for the presence of aflatoxin bi...

Alpha Thalassemia is one of the most prevalent disorders worldwide with a [T1] high carrier rate in Mazandaran province (north of Iran). Carriers of --MED double gene deletion are at risk of having a child with hemoglobin  haemoglobin[T2]  H (HbH) disease, if they marry a silent carrier. Co-inheritance of αααAnti3.7 triplication that cannot be detected using hem...