New high-resolution high signal-to-noise spectra of the z = 1.15 damped Lyman α (DLA) system toward the quasi-stellar object HE 0515-4414 reveal absorption lines of the multiplets 2 and 3 in C i. The resonance lines are seen in two components with total column densities of logN = 13.79 ± 0.01 and logN = 13.36 ± 0.01, respectively. The comparision of theoretical calculations of the relative fine...

the present investigation was focused to formulate semi-solid capsules (sscs) of hydrophobic drug telmisartan (tlms) by encapsulating semi-solid matrix of its solid dispersion (sd) in hpmc capsules. the combinational approach was used to reduce the lag time in drug release and improvise its dissolution. sds of tlms was prepared using hot fusion method by varying the combinations of pluronic-f68...

The cysteine allele of the amino acid polymorphism (AAP) Y/C1584 in the A2 domain of von Willebrand factor (VWF) has been shown to correlate with enhanced VWF proteolysis by ADAMTS13. The frequencies and effect on VWF proteolysis of six reported AAP in VWF domains A1 and A2 were investigated. Only two AAP were variant: 4414 G/C (D/H1472) (allele frequency 0.86/0.14) and 4693 G/T (V/L1565) (alle...