Successful culturing of tissues within polysaccharide hydrogels is reliant upon specific mechanical properties. Namely, the stiffness and elasticity of the gel have been shown to have a profound effect on cell behaviour in 3D cell cultures and correctly tuning these mechanical properties is critical to the success of culture. The usual way of tuning mechanical properties of a hydrogel to suit t...

Food powders were applied on crackers that had been coated using water, oil, emulsion, sucrose, or hydrocolloid solutions. The hydrocolloids that were used include gellan gum, kappa-carrageenan, methylcellulose, gum karaya, gum tragacanth, gum arabic, guar gum, modified starch, and maltodextrin. Solutions of similar hydrophobicity to the powder gave the greatest adhesion. NaCl, barbecue (BBQ), ...

Objective: The objective of the current investigation was to design aceclofenac encapsulated microbeads using gellan gum and linseed blends following ionotropic gelation by trivalent Al3+-ions as cross-linking agent. Methods: Various formulation parameters like polymer-polymer blend (gellan gum), proportion concentration aluminium chloride (i.e., cross-linker) were considered for preparation di...

Gellan gum is a biocompatible and easily accessible polysaccharide with excellent properties to produce microparticles as drug delivery systems. However, the production methods often fail in reproducibility, compromising translational potential of such In this work, gellan gum-based was optimized using coaxial air flow method, an inexpensive reproducible method. A design experiments used identi...

It has been demonstrated that bone marrow mesenchymal stem cell (BM-MSCs) transplantation has beneficial effects on several central nervous system (CNS) debilitating conditions. Growing evidence indicate that trophic factors secreted by these cells are the key mechanism by which they are acting. These cells are frequently used in combination with 3D artificial matrices, for instance hydrogels, ...

The mechanical characteristics of ionic-covalent entanglement hydrogels consisting of combinations of the biopolymers gellan gum and kappa-carrageenan, and the synthetic polymers polyacrylamide and an epoxy amine were investigated. Compression testing showed that these gels exhibited "double network" behavior, i.e. strong tough gels.

The present investigation was aimed to formulate and characterize ion-activated in-situ gel loaded with Rizatriptan Benzoate (RIZ) for intranasal administration brain targeting. further optimized process formulation parameters by using 32 factorial design. batch having the concentrations of gellan gum HPMC E15 LV 33.83 mg 9.6 respectively. Gel strength mucoadhesive were found be 32.54 sec 2580....

The dairy industry produces large quantities of whey as a by-product of cheese production and is increasingly looking for new ways to utilize this waste product. Gellan gum is reliably produced by Sphingomonas paucimobilis in growth media containing lactose, a significant component of cheese whey, as a carbon source. We studied and compared polysaccharide biosynthesis by S. paucimobilis ATCC 31...