Accumulating evidence suggests that glycogen synthase kinase 3 (GSK-3) is a multifunctional kinase implicated in neuronal development,mood stabilization, andneurodegeneration. However, the synaptic actions of GSK-3 are largely unknown. In this study,we examined the impact ofGSK-3 onAMPAreceptor (AMPAR) channels, the major mediator of excitatory transmission, in cortical neurons. Application of ...

PURPOSE Rho family members are small GTPases that are known to regulate malignant transformation and motility of cancer cells. The activities of Rhos are regulated by molecules such as guanine nucleotide dissociation inhibitors (GDIs). This study determined the levels of expression and the distribution of Rho-A, -B, -C, and -G, and Rho-6, -7, and -8, as well as Rho-GDI-beta, and Rho-GDI-gamma, ...

Low power 8 bit GDI magnitude comparator is proposed in this paper which has an advantage of minimum power dissipation, reduced propagation delay and less number of transistors required as compare to conventional CMOS magnitude comparator. Proposed GDI magnitude comparator is designed at 100MHz frequency with 1.8 v supply voltage using 180nm technology using CADENCE VLSI EDA tools. The performa...

Full Swing Gate Diffusion Input (FS-GDI) methodology is presented. The proposed methodology is applied to a 40 nm Carry Look Ahead Adder (CLA). The CLA is implemented mainly using GDI full-swing F1 and F2 gates, which are the counterparts of standard CMOS NAND and NOR gates. A 16-bit GDI CLA was designed in a 40 nm low power TSMC process. The CLA, implemented according to the proposed methodolo...

An axial–azimuthal two-dimensional Hall thruster discharge model was developed for analyzing gradient drift instability (GDI) and cross field electron transport enhancement induced solely by the GDI. A hybrid particle-fluid used partially ionized plasma, where inertialess fluid in quasineutral plasma assumed. nonoscillatory numerical method proposed potential solver to avoid analyze physics of ...

The low power techniques are becoming more important due to rapid development of portable digital applications; demand for high-speed and low power consumption.GDI (Gate Diffusion Input) is one of the low power and area efficient technique. GDI requires less number of transistors compared to CMOS technology. The basic cell of GDI consists of two transistors where three terminals i.e Gate, Sourc...

This paper presents a design of low power, area efficient radix 4 booth multiplier using gated diffusion input(GDI) technique and modified gated diffusion input technique. MGDI and GDI plays an important role in design of low power and area efficient circuits. This has led many researchers to take GDI and MGDI technique very seriously in building important circuits related to advanced low power...

Now–a-days in digital circuits design high speed, high throughput, small silicon area, and at the same time, lowpower consumption of digital circuit is most important things for digital circuit designers. In this paper a novel design method of a low power digital circuit is discussed, where the GATE DIFFUSION INPUT (GDI) technique has been used for the simultaneous generation of digital logic f...

We have previously purified from bovine brain cytosol a novel regulatory protein for smg p25A, a ras p21-like GTP-binding protein. This protein, named smg p25A GDP dissociation inhibitor (GDI), regulates the GDP/GTP exchange reaction of smg p25A by inhibiting the dissociation of GDP from and thereby the subsequent binding of GTP to it. We have also previously found that smg p25A is mainly local...

Gastroenterological disorders are very common at hyperbaric conditions. The present study was conducted to find out the impact of gut flora on the gastrointestinal disorders created at such environmental circumstances. For this, male albino rat were exposed to graded hyperbaric pressures (915 and 1277 mmHg) and large intestinal content was examined for microbial composition using culture based ...