Large numbers of gross chromosomal rearrangements (GCRs) are frequently observed in many cancers. High mobility group 1 (HMG1) protein is a non-histone DNA-binding protein and is highly expressed in different types of tumors. The high expression of HMG1 could alter DNA structure resulting in GCRs. Spt2p is a non-histone DNA binding protein in Saccharomyces cerevisiae and shares homology with ma...

This review analyzes an interdisciplinary approach to the pancreatic endocrine network-like relationships that control glucagon secretion and glucagon counterregulation (GCR). Using in silico studies, we show that a pancreatic feedback network that brings together several explicit interactions between islet peptides and blood glucose reproduces the normal GCR axis and explains its impairment in...

This paper considers the problem of placing a single rectangular generalized congested region (GCR) of given area but unknown dimensions in the presence of other rectangular GCRs, where the edges of the rectangles are parallel to the travel axes. GCRs are closed and bounded regions in 2 in which facility location is prohibited but travel through is allowed at an additional cost per unit distanc...

We address the problem of two pairs of fermions living on an arbitrary number of single particle levels of a potential well (mean field) and interacting through a pairing force. The associated solutions of the Richardson’s equations are classified in terms of a number vl, which reduces to the seniority v in the limit of large values of the pairing strength G and yields the number of pairs not d...

This paper presents the implementation and performance evaluation of our proposed BGP-GCR+ routing architecture via simulation in ns-2. BGP-GCR+ consists of three components: (1) a two-level hierarchical, non-overlapped, one-node fault-tolerant routing algorithm for large-scale mobile ad-hoc networks (MANETs), (2) an IPv6-based address stateless auto-configuration scheme, and (3) procedures at ...

Long-duration observations of Neptune’s brightness in two visible wavelengths provide a disk-averaged estimate of its atmospheric aerosol. Brightness variations were previously associated with the 11-year solar cycle, through solar-modulated mechanisms linked with either ultra-violet (UV) or galactic cosmic ray (GCR) effects on atmospheric particles. Here we use a recently extended brightness d...

Glucocorticoids (GC) are highly effective in the control of diseases associated with T cell activation. However, a subset of individuals is GC insensitive. Previous studies have demonstrated that IL-2 can induce steroid resistance in mouse T cells. However, the mechanism for this phenomenon is unknown. In the current study we found that the murine cell line (HT-2) is steroid resistant when incu...

Global catastrophic risks (GCRs) are risks of events that could significantly harm or even destroy civilization at the global scale. GCR raises a number of profound ethical issues, with a range of ethical theories suggesting that GCR reduction should be society’s top priority. This paper discusses GCR ethics in the context of dual-use bioengineering: bioengineering that can cause either benefit...