The multikinase inhibitor and FDA-approved drug dovitinib (Dov) crosses the blood-brain barrier and was recently used as single drug application in clinical trials for GB patients with recurrent disease. The Dov-mediated molecular mechanisms in GB cells are unknown. We used GB patient cells and cell lines to show that Dov downregulated the stem cell protein Lin28 and its target high-mobility gr...

Stable transfectants were selected from human astrocytoma cells (U373) after transfection with recombinant expression vectors carrying the human cytomegalovirus (HCMV) glycoprotein B (gB; gpUL55) gene with alternative deletions of hydrophobic domain segment 1 (hd1) or segment 2 (hd2) of the carboxy-terminal potential bipartite membrane anchor domain. Comparative analysis of HCMV gB forms from c...

the hepatitis g virus (hgv) is a newly discovered rna virus, which is associated with acute or chronic hepatitis. a survey was conducted in thalassemic patients, intravenous drug users (ivdu) and blood donors aiming to investigate the prevalence of hepatitis g virus (hgv) infection in these groups in tehran. the presence of hgv rna in these populations was determined using reverse transcriptase...

conclusions overall, results of present study were consistent with the data reported earlier base on 5’ ntr in iranian isolates and revealed genotype ir2 is major genotype in iranian hgv-positive patient. it means there are higher similarities between iranian and europe-usa in hgv ns3 gene. results nucleotide blast results emphasized that most similar sequences to ir ns3 sequences were those fr...

BACKGROUND Both gastric bypass (GB) and duodenal switch with sleeve gastrectomy (DS) have been widely used as bariatric surgeries, and DS appears to be superior to GB. The aim of this study was to better understand the mechanisms leading to body weight loss by comparing these two procedures in experimental models of rats. METHODS Animals were subjected to GB, DS or laparotomy (controls), and ...

Among the compatible solutes, glycine betaine (GB) is particularly an effective osmolyte against abiotic stress. Metabolic acclimation of GB is regarded as a basic strategy for the protection and survival of plants in harsh environmental conditions. Plant species vary in their capacity to synthesize GB. Some plants, such as spinach and barley, accumulate relatively higher levels of GB in their ...

OBJECTIVE Gastric bypass (GB) surgery is associated with postprandial hyperinsulinemia, and this effect is accentuated in postsurgical patients who develop recurrent hypoglycemia. Plasma levels of the incretin glucagon-like peptide 1 (GLP-1) are dramatically increased after GB, suggesting that its action contributes to alteration in postprandial glucose regulation. The aim of this study was to ...

The glycogen body (GB) is at the dorsal area of the lumbosacral spinal cord in birds and is composed of uniform cells that are characterized by high-glycogen storage. Previous morphological and embryological examinations suggest that the GB is derived from the neuroepithelium and contains many blood vessels and a few nerve fibers. However, the function of the GB and role of the glycogen are unk...

The identification of "asymptomatic" (i.e., protective) epitopes recognized by T cells from herpes simplex virus (HSV)-seropositive healthy individuals is a prerequisite for an effective vaccine. Using the PepScan epitope mapping strategy, a library of 179 potential peptide epitopes (15-mers overlapping by 10 amino acids) was identified from HSV type 1 (HSV-1) glycoprotein B (gB), an antigen th...

Ginseng extract has been shown to possess certain anti-virus, anti-tumor and immune-activating effects. However, the immunostimulatory effect of ginseng berry extract (GB) has been less well characterized. In this study, we investigated the effect of GB on the activation of mouse dendritic cells (DCs) in vitro and in vivo. GB treatment induced up-regulation of co-stimulatory molecules in bone m...