Metoprolol succinate (MS) gastroretentive (GR) controlled release system was formulated to increase gastric residence time leading to improved drug bioavailability. Box-Behnken model was followed using novel combinations of sodium alginate (SA), sodium carboxymethylcellulose (NaCMC), magnesium alumino metasilicate (MAS) as independent variables. Floating lag time (Flag), t25, t50, t75, diffusio...

Gastroretention is the mechanism by which a dosage form is retained in the stomach, generally for the purposes of improving drug delivery. It has been proposed as a mechanism through which drug absorption in the upper gastrointestinal tract can be maximised. Gastroretentive approaches to drug delivery aim to counteract the physiological mechanisms that cause the stomach to empty by providing a ...

Sustained release gastroretentive dosage forms enable prolonged and continuous input of the drug to the upper parts of the gastrointestinal (GI) tract and improve the bioavailability of medications that are characterized by a narrow absorption window. A new strategy is proposed for the development of gastroretentive dosage forms for ofloxacin preferably once daily. The design of the delivery sy...

Purpose: The aim of this work was to synthesize superporous hydrogels of rosiglitazone using chitosan and to study its swelling behaviour for application as a gastroretentive drug delivery system. Methods: Chitosan superporous hydrogels were synthesized using glyoxal as a crosslinking agent by gas blowing method. The effect of pH and ionic strength on the swelling ratio was determined. Swelling...