Simvastatin appeared to have additional benefits beyond their lipid lowering effects, which has led to interest in the use of this class of drugs outside the field of cardiovascular disease. Aim: This study aimed to investigate the possible gastroprotective effect of simvastatin against both indomethacin and cold restraint stress (CRS) induced gastric ulcers in rats and to study its effect on g...

conclusions our results showed that mo extract may have a gastroprotective effect against experimental gastric ulcers in rats. the exact mechanism has not yet been determined, but it may be due to enhancing enzymatic antioxidant defenses and inhibiting lipid peroxidation. materials and methods male wistar rats (200 - 250 g) were starved for 24 hours prior to the induction of gastric ulceration ...

Gastric ulcer (GU) is the most common health concern that occurs due to alcohol consumption, smoking and physiological stress. Boswelia dalzielii (BD) traditionally used treat many diseases including gastric ulcers. This study aims investigate gastroprotective activity of Boswelia dalzielii. The cytoprotective property was evaluated by using five experimental methods GU: 1. Absolu...

aloe buettneri a. berger is commonly used in traditional togolese medicine to treat inflammatory and gastric ulcers. the present study examined the gastro-protection effect of the hydro-alcoholic extract of a. buettneri on mucus production and gastric ph. a gastric ulcer is induced by ethanol 95° alone (1 ml/kg body weight), after pre-treatment with indomethacin (300 mg/kg) or by utilising l-na...

The herbal medicines derived from various plants extracts are being increasingly utilized to treat a wide variety of clinical diseases 1 . Besides their action as gastroprotectives, flavonoids also act in healing of gastric ulcers 2 . The study was designed to investigate the anti-ulcer effect of chloroform extract of Chrozophora plicata leaves (600mg/kg) against experimentally induced ulcer mo...

we have studied the ulcerogenic effect of indomethacin in stretozocin. induced diabetic rats. streptozocin (65 mg kg-1) was injected intraperitoneally to male wistar rats. the blood glucose concentration was determined continuously. blood glucose level increased significantly (p<0.001) after 30 days. gastric erosions were induced by intraperitoneal injection of indomethacin (50 mg kg-1) in fast...

OBJECTIVE To investigate the role of endothelin on nonsteroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 (COX2) enzyme inhibitors-induced effects on the gastric mucosa. METHODS This study was carried out in the Department of Pharmacology Laboratory, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey during the period January to December 2002. In the first group ...

TNF-alpha has numerous biological activities, including the induction of chemokine expression, and is involved in many gastric injuries. C-C chemokines [monocyte chemotactic protein (MCP)-1 and macrophage inflammatory protein (MIP)-1alpha] and C-X-C chemokines [MIP-2 and cytokine-induced neutrophil chemoattractant (CINC)-2alpha] mediate chemotaxis of monocytes and neutrophils, respectively. We ...

OBJECTIVE Cod liver oil is used widely as a dietary supplement. The present study was carried out to evaluate the effect of cod liver oil (0.5 g/kg, p.o. and 1 g/kg, p.o.) on gastric and duodenal ulcers. MATERIALS AND METHODS The study was carried out on different gastric ulcer models such as acetic acid induced chronic gastric ulcers, pylorus ligation, indomethacin induced ulcers, stress ind...

Background: Gastric ulcer is among the most serious stomach disorder universally. Several effective drugs are employed in the management of this disease, although there have been adverse effects in some cases. The aim of this study was to investigate the effect of nortriptyline to protect against gastric lesions, induced by indomethacin or cold-stress in rats. Methods: Gastric lesions were ind...