A Peptic ulcer is a mucosal lesion of the stomach or duodenum in which the acid and pepsin play major pathogenic roles. The major forms of peptic ulcer are gastric ulcer and duodenal ulcer, both of which are chronic diseases often caused by Helicobacter pylori. The term peptic ulcer also encompasses gastric ulcers and duodenal ulcers associated with stress or the ingestion of drugs, most common...

thyroid hormoned are known to influence acid and pepsin secretion,though exact mechanism(s) are not fully understood.in this study distention-stimulated acid and pepsin secretionof hypo and hyperthyroid rats were compared with controls.each group consisted of 8 N-mari rats from both sexs,weighing  246.6+_9.2g. hypo and hyper thyroid states were induced by administration of methimazole(500mg/l H...

OBJECTIVES To determine the frequency of pepsin detection in tracheal aspirate (TA) samples of mechanically ventilated premature neonates and its association with feedings and methylxanthine therapy. PATIENTS AND METHODS Serial TA samples (days 1, 3, 5, 7, 14, 21, 28 and >28 days) were collected from premature neonates receiving ventilatory support. An enzymatic assay with a fluorescent subst...

OBJECTIVE To investigate the contribution of pepsin to inflammation attributed to nonacidic gastric reflux via analysis of inflammatory cytokine and cytokine receptor gene expression in pepsin-treated human hypopharyngeal epithelial cells in vitro. STUDY DESIGN Translational research. SETTING This study was performed in an academic research laboratory. SUBJECTS AND METHODS Human hypophary...

BACKGROUND Endotracheal intubation increases the risk for microaspiration of secretions around the tube cuff. Pepsin has been used as a biomarker for gastric aspiration. Amylase is a newer proposed biomarker for aspiration of oral contents. OBJECTIVE To assess the presence of pepsin and amylase in paired oral-tracheal secretions of adult patients treated with mechanical ventilation. METHODS...

Some patients with idiopathic pulmonary fibrosis experience acute exacerbations in their respiratory status leading to substantial morbidity and mortality. Occult aspiration of gastric contents has been proposed as one possible mechanism leading to these acute exacerbations. We sought to determine whether pepsin, a marker of gastric aspiration, is elevated in bronchoalveolar lavage fluid obtain...

BACKGROUND/AIMS Paraoxon, an organophosphate metabolite of the insecticide parathion inhibits the enzyme, acetylcholinesterase (Achase). Organophosphates affect the heart, visual system, nervous system and muscles. In this present study, we investigate the effects of the chronic consumption of paraoxon on gastric acid and pepsin secretion in N-mari rats. MATERIALS AND METHODS This study was p...

Natural pigments are high value molecules for food industry as well pharmacy, perceived the best choice today’s consumers given their origin and safety. However, its use is limited by lability which hinders application in products. In this work there was evaluated stability of phycocyanin C gelatin candies when added with trehalose citric acid; formulated were digested synthetic gastric juice p...

Helicobacter pylori gastritis is common, but effects on gastric secretion are not well understood. We measured basal and pentagastrin-stimulated gastric acidity, pepsin activity, and fluid output, as well as serum gastrin concentrations and H. pylori antibody levels, before and after treatment of H. pylori gastritis in 28 men and women. Subjects were studied before and 1 and 3 mo after a course...