Hyperacidity in the stomach is known to promote the progression of gastric cancer. The plant-derived chemotherapeutic curcumin is used to treat gastric cancer. The objective of this study was to investigate whether curcumin regulates gastrin-mediated acid secretion in suppressing gastric cancer. Gastric cancer cells were treated with 25 μm curcumin, followed by Annexin V/propidium iodide double...

It is now recognized that there is a two-way interaction between Helicobacter pylori gastritis and gastric physiology. H. pylori gastritis can alter gastric physiology, leading to increased or decreased acid secretion depending on the pattern of gastritis present. These changes in physiology are related to the disease outcome, with increased acid secretion leading to duodenal ulcer disease and ...

BACKGROUND It is well established that the esophageal distention (ED) leads to gastric relaxation, partly by vago-vagal reflex, but till now, the effect of ED on gastric acid secretion has not been investigated. The aim of this study was to investigate the effect of ED on basal and stimulated gastric acid secretion. METHODS Adult male Wistar rats (200-240 g) were deprived of food but not the ...

Several neuropeptides injected intracisternally were assessed for their effects on gastric secretion in rats. Bombesin (1 microgram) completely suppressed gastric acid secretion, produced the volume of gastric secretion, and partially blocked insulin- or 2-deoxy-D-glucose-induced stimulation of gastric acid output. The inhibitory effect of this peptide is dose-dependent, long-acting, reversible...

Objective(s): Transforming growth factor alpha (TGF-α) has been shown to modulate the gastric acid secretion. Therefore, the aim of the present study was to investigate the effect of sodium hydrosulfide (NaHS) on TGF-α expression in gastric mucosa in rats. Materials and Methods: Eighteen rats were randomly divided into 3 groups (6 per group). To determine the effect of NaHS on gene and protein ...

We have previously demonstrated that intracisternal orexin-A potently stimulated gastric acid secretion through the vagus nerve. Considering its stimulatory action on feeding, we hypothesized that orexin-A is a candidate mediator of cephalic phase gastric secretion. It has also been suggested that the stimulation of acid by central orexin-A may be mediated by orexin 1 receptor (OX1R) in the bra...

objective(s) ziziphora clinopodioides lam. is a plant widely used in iranian traditional medicine for gastrointestinal disorders. several reports have demonstrated antibacterial (helicobacteria pylori), antioxidant and anti­inflammatory properties of z. clinopodioides. the aim of this study was to investigate the effects of aqueous- ethanol extract of z. clinopodioides on rat’s gastric acid out...

Feldman, Mark, Byron Cryer, Doug Sammer, Edward Lee, and Stuart J. Spechler. Influence of H. pylori infection on meal-stimulated gastric acid secretion and gastroesophageal acid reflux. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G1159–G1164, 1999.—Gastric acid secretion, gastrin release, gastric emptying, and gastroesophageal acid reflux were measured in asymptomatic individuals bef...

Motilin and ghrelin constitute a peptide family, and these hormones are important for the regulation of gastrointestinal motility. In this study, we examined the effect of motilin and ghrelin on gastric acid secretion in anesthetized suncus (house musk shrew, Suncus murinus), a ghrelin- and motilin-producing mammal. We first established a gastric lumen-perfusion system in the suncus and confirm...

A histamine test meal is described for the estimation of the secretion of gastric acid and pepsin in the unanaesthetized intact rat. The stomach of the rat secreted pepsin and a small amount of acid in response to the test meal of hypertonic sucrose. Stimulation with histamine produced a pronounced rise in acid secretion but the output of pepsin remained unchanged. The increase in acid secretio...