Sialic acids have been found to mask antigens, receptors and other recognition sites on molecules and cells. This has been investigated best with hepatocyte and macrophage lectins which recognize 13-galactose and N-acetyl-13-galactosamine residues on molecules and cells exposed by sialidase treatment. The lectin on macrophages leads to the binding and phagocytosis of erythrocytes after the enzy...

A validated method for the quantitative determination of venlafaxine, O-desmethylvenlafaxine in human plasma by tandem liquid chromatographymass spectrometry (HPLC/MS/MS) has been proposed. Sample preparation was carried out liquid-phase extraction with support (SLE, from «supported extraction») using HyperSEP cartridges and washing 3-methylbutyl ether. The measure target analytes on a triple q...

We are now launching the first issue of the first volume of the International Journal of Analytical Mass Spectrometry and Chromatography (IJAMSC). This newly launched journal is an open access journal, whose primary aim is to provide a platform for researchers and practitioners, worldwide, to promote, share, and discuss various new issues and developments in all areas of Mass Spectrometry and C...

Clinical Medicine Vol 8 No 6 December 2008 621 © Royal College of Physicians, 2008. All rights reserved. It has been over a century since Sir Archibald Garrod first recognised the existence of inherited metabolic diseases (IMD).1 Technological and scientific advances have gradually led to greatly increased understanding of their aetiology and pathogenesis, and have ultimately resulted in effect...

background ziziphora tenuior l. known as kakuti in persian, is used in traditional medicine for fever, dysentery, uterus infection and as an analgesic. it is used also in the treatment of gastrointestinal disorders as carminative, or remedy of diarrhea or nausea. major components of plant essential oil including pulegone, isomenthone, thymol, menthone, and piperitone are suggested to be respons...

background food born pathogenic bacteria are the most important agents of infections in humans, and food spoilage also results in economic losses in food industry. objectives the aim of this study was the evaluation of chemical components, total phenolic content, antioxidant and antibacterial activities of artemisia dracunculus essential oil. materials and methods the essential oil of tarragon ...

background: cocaine poisoning is known for causing severe clinical effects such as tachycardia, hypertension, agitation and confusion. absence of clinical manifestations in cocaine poisoning is unusual. case report: a 26-year old man, known to be a cocaine addict, declared that he was forced by cocaine dealers to swallow many tablets of cocaine, six hours prior to admission to emergency departm...