The Golgi-Associated Retrograde Protein (GARP) complex is a tethering factor involved in the fusion of endosome-derived transport vesicles to the trans-Golgi network through interaction with components of the Syntaxin 6/Syntaxin 16/Vti1a/VAMP4 SNARE complex. The mechanisms by which GARP and other tethering factors engage the SNARE fusion machinery are poorly understood. Herein, we report the st...

62 Computer The Garp Architecture and C Compiler V arious projects and products have been built using off-the-shelf field-programma-ble gate arrays (FPGAs) as compute accelerators for specific tasks. Such systems typically connect one or more FPGAs to the host computer via an I/O bus. Some have shown remarkable speedups, albeit limited to specific application domains. Many factors limit the gen...

Two predictive models were developed within a geographic information system using Genetic Algorithm Rule-Set Prediction (GARP) and the growing degree day (GDD)-water budget (WB) concept to predict the distribution and potential risk of visceral leishmaniasis (VL) in the State of Bahia, Brazil. The objective was to define the environmental suitability of the disease as well as to obtain a deeper...

The multisubunit Golgi-associated retrograde protein (GARP) complex is required for tethering and fusion of endosome-derived transport vesicles to the trans-Golgi network. Mutation of leucine-967 to glutamine in the Vps54 subunit of GARP is responsible for spinal muscular atrophy in the wobbler mouse, an animal model of amyotrophic lateral sclerosis. The crystal structure at 1.7 A resolution of...

Without question, the adoption of FAS 133 will have an impact on the way firms use derivatives. One application that will certainly be affected is the use of currency swaps in conjunction with funding in a currency other than the functional currency. In the past, synthetic instrument accounting ruled. Under that regime, the accounting did not distinguish between issuing fixed rate debt directly...

Global climate change has created a major threat to biodiversity. However, little is known about the habitat and distribution characteristics of Cinnamomum camphora (Linn.) Presl., an evergreen tree growing in tropical subtropical Asia, as well factors influencing its distribution. The present study employed Maxent GARP establish potential model for target species based on 182 occurrence sites ...

Ahmet Hamdi Tanpınar, Türk edebiyatında eserleri üzerine en çok fikir belirtilen, metinler yazılan isimlerdendir. Hakkında yapılan güncel çalışmalar da bu durumun devam edeceğini göstermektedir. Roman, hikâye, deneme yazarı, şair, akademisyen kimlikleri ile yaşadığı zamana ve sosyal hayata dair tespitleri, mazi hâl arasında kurduğu ilişkiler, dildeki yetkinliği her geçen gün okur kitlesinin art...

In the world according to Garp, we are all terminal cases.

In this paper we investigate the cognitive plau-sibility of an integrated framework for qualitative prediction of behaviour. The framework is based on the KADS expertise modeling approach and integrates diierent approaches to qualitative reasoning. The framework is implemented in a program called GARP. To test the cognitive plau-sibility a physics problem involving qualitative prediction of beh...

Typical reconfigurable machines exhibit shortcomings that make them less than ideal for general-purposecomputing. The Garp Architecture combines reconfigurable hardware with a standard MIPS processor on the same die to retain the better features of both. Novel aspects of the architecture are presented, as well as a prototype software environment and preliminary performance results. Compared to ...