background : the study was aimed to show the effect of molecular mechanism of aqueous garlic extract (age) on expression of ifnγ and inos genes in leishmania major . methods : leishmania major promastigotes (mrho/ir/75/er) were added to the in-vitro cultured j774 cell line, the cells were incubated for 72 hours. various concentrations of garlic extract (9.25, 18.5, 37, 74, 148 mg/ml) were added...

BACKGROUND Garlic is one of the medicinal plants which has showed beneficial effects on atherosclerosis risk factors. The liver X receptor α (LXRα) is an important regulator of cholesterol, triglyceride and glucose homeostasis that belongs to the nuclear receptor superfamily. In this study we investigated the effect of garlic on lipid profile, glucose as well as LXRα expression in intestine and...

Clinical and experimental evidence indicates that garlic ingestion lowers blood cholesterol levels, and treatment of cells in culture with garlic and garlic-derived compounds inhibits cholesterol synthesis. To identify the principal site of inhibition in the cholesterolgenic pathway and the active components of garlic, cultured hepatoma cells were treated with aqueous garlic extract or its chem...

BACKGROUND: Garlic (Allium sativum) is known for its anti-bacterial properties, but information on its effects against bacteria species that are important in fish diseases is scarce. OBJECTIVES: The aim of this research was to use garlic as a natural product to improve the aquatic animal health status so as to compensate the demand for environment-friendly products for sustainable aquacultur...

Introduction: Increasing rate of candidiasis prevalence and consequently use of antifungal drugs as prophylactic and curative agents has led to the widespread emergence of resistant strains. Therefore this study was designed to evaluate the in vitro antifungal activity of an aqueous extract of garlic and the synergic effect of garlic extract with fluconazole against common clinical isolates of ...

Garlic extracts have been shown to decrease drug exposure for saquinavir, a P-glycoprotein and cytochrome P450 3A4 substrate. In order to explore the underlying mechanisms and to study the effects of garlic on pre-systemic drug elimination, healthy volunteers were administered garlic extract for 21 days. Prior to and at the end of this period, expression of duodenal P-glycoprotein and cytochrom...

Although extracts of garlic inhibit cholesterol biosynthesis in cultured hepatocytes, the inhibitory components of garlic and the site or sites of inhibition in the cholesterol biosynthetic pathway have not been established. To elucidate potential mechanisms of inhibition, we examined the effect of fresh garlic extract and 16 water- or lipid-soluble compounds derived from garlic on purified rec...

objective: garlic is a plant has been used as a flavor, and anti-microbial and anti-diarrheal agent. infectious bronchitis virus (ibv) is a coronavirus. the available vaccines against ibv cannot cover new variants. this study evaluated the inhibitory effects of garlic extract on ibv.  materials and methods: the constituents of garlic extract were detected by gas chromatography. this study was d...

the effects of dietary supplementation of garlic (allium sativum)extract on the growth and disease resistance of african catfish, clarias gariepinus was evaluated. also in-vitro evaluation of susceptibility of fish-borne multidrug resistant (mdr) pathogenic bacteria to aqueous extract of garlic was done. aqueous garlic extract exhibited inhibitory activity against mdr bacteria and the degree of...