THE importance of infectious hepatitis as a world-wide problem has been highlighted in detail during the presentations made at this symposium. It is clear that as of today (May I 8, I968) there is no published report confirming the isolation of infectious hepatitis virus in a tissue-culture system or animal host. Experience with poliomyelitis, measles, and rubella has revealed that the time int...

An immunological study of 21 myeloma sera was carried out to determine their relationship to components of normal gamma-globulin and to each other. Ten proteins were separated for detailed characterization. Every one of the myeloma proteins studied was immunologically different, indicating individual specificity. The gamma-type myeloma proteins were all related to normal gamma-globulin or a fra...

The antigenic properties of normal 19S gamma-globulin, pathologic macroglobulins, beta(2A)-myeloma proteins, and Bence Jones proteins have been compared with 7S gamma-globulin and the small 3.5S units derived from it by gel diffusion precipitin techniques. These studies demonstrate that the determinant groups on the 7S gamma-globulin molecule responsible for the cross-reaction with each of the ...

Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disease defined by a low platelet count secondary to accelerated platelet destruction by anti-platelet antibodies. The resulting bleeding diathesis can present a therapeutic dilemma. We have treated two cases of ITP in which ureteral stones were successfully extracted by transurethral ureterolithotripsy (TUL) and extracorporeal shock wa...

The catabolism of homologous and heterologous 7S gamma globulin fragments obtained by pepsin and papain digestion was studied in rabbits, guinea pigs, and mice. The elimination from the circulation of I* labeled gamma globulin fragments was followed and the urinary excretion of the total and protein-bound I* activity determined. Evidence is presented that the molecular structure responsible for...

The aim of this study was to determine for reference purposes the values of serum albumin, alpha 1-globulin, alpha 2-globulin, beta-globulin, gamma-globulin, and alpha-lipoprotein (high density lipoprotein), pre-beta-lipoprotein (very low density lipoprotein) and beta-lipoprotein (low density lipoprotein) fractions of normal ostriches (Struthio camelus) in Turkey. Five male and five female ostr...

Infection of mice with the lactic dehydrogenase virus (LDV) resulted in an elevated level of gamma-globulin. Histologic examination of the spleen and lymph nodes revealed that the number of germinal centers was greatly increased. Immunization with human gamma-globulin showed that the capacity of the virus-infected animal to produce anti-human gamma-globulin was greatly enhanced and that the vir...

Highly purified C'1 esterase of human serum is capable of inactivating isolated fourth component of human complement (beta(1E)-globulin). Inactivation is accompanied by changes in electrophoretic and ultracentrifugal properties of beta(1E)-globulin. If non-sensitized sheep erythrocytes are present during the action of C'1 esterase on beta(1E)-globulin, a complex is formed consisting of cells an...

BACKGROUND We evaluated a new, automated multicapillary zone electrophoresis (CE) instrument (Capillarys), 4.51 software version; Sebia) for human serum protein analysis. METHODS With the Capillarys beta1-beta2+ reagent set, proteins were separated at 7 kV for 4 min in 15.5 cm x 25 micro m fused-silica capillaries (n = 8) at 35.5 degrees C in a pH 10 buffer with online detection at 200 nm. Se...